Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report

  • Authors:
    • Defeng Zhao
    • Liren Qian
    • Jianliang Shen
  • View Affiliations

  • Published online on: September 12, 2014     https://doi.org/10.3892/ol.2014.2527
  • Pages: 2634-2636
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Abstract

Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome, is an aggressive hyperinflammatory condition characterized by prolonged fever, cytopenias and hepatosplenomegaly, as well as hemophagocytosis by activated, morphologically benign macrophages. HLH may be characterized into two forms, familial and secondary HLH. Familial HLH usually manifests in children with genetic abnormalities associated with the cytotoxic function of NK and T cells, whereas secondary HLH usually occurs in older patients in combination with an associated condition, such as infection or malignancy, without an identifiable genetic abnormality. Malignancy‑associated hemophagocytic lymphohistiocytosis is mostly accompanied by lymphoid neoplasms. The present study reports a rare case of this syndrome in combination with acute myeloblastic leukemia (AML‑M2), in a patient with clonal karyotypic abnormalities. The patient was successfully treated with chemotherapy comprising daunorubicin (40 mg/m2 i.v., days 1‑3) and cytosine arabinoside (100 mg/m2, 1‑h i.v. infusion, days 1‑7). All clinical symptoms disappeared following chemotherapy.
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December-2014
Volume 8 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao D, Qian L and Shen J: Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report. Oncol Lett 8: 2634-2636, 2014.
APA
Zhao, D., Qian, L., & Shen, J. (2014). Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report. Oncology Letters, 8, 2634-2636. https://doi.org/10.3892/ol.2014.2527
MLA
Zhao, D., Qian, L., Shen, J."Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 8.6 (2014): 2634-2636.
Chicago
Zhao, D., Qian, L., Shen, J."Acute myelocytic leukemia in a patient with hemophagocytic lymphohistiocytosis: A case report". Oncology Letters 8, no. 6 (2014): 2634-2636. https://doi.org/10.3892/ol.2014.2527