14‑3‑3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer

  • Authors:
    • Yi‑Liang Li
    • Lihua Liu
    • Yang Xiao
    • Tao Zeng
    • Chao Zeng
  • View Affiliations

  • Published online on: November 6, 2014     https://doi.org/10.3892/ol.2014.2676
  • Pages: 290-294
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

14‑3‑3 proteins participate in various cellular processes, including apoptosis, proliferation and malignant transformation. 14‑3‑3σ, a member of the 14‑3‑3 protein family, is important in several types of cancer; however, little is known about the clinical significance and biological roles of 14‑3‑3σ in gastric cancer. The present study analyzed the expression pattern of 14‑3‑3σ in gastric cancer and investigated its correlation with the prognosis of gastric cancer patients. Furthermore, the association of 14‑3‑3σ with Ki‑67, Bcl‑2 and Bax was evaluated. 14‑3‑3σ was expressed at higher level in gastric cancer tissue compared with healthy gastric tissue, and 14‑3‑3σ expression was significantly correlated with tumor size and tumor node metastasis stage (P<0.05). To the best of our knowledge, the present study data are the first to suggest that 14‑3‑3σ expression has been significantly associated with poor prognosis in gastric cancer. Additionally, 14‑3‑3σ overexpression was positively correlated with Ki‑67 and Bcl‑2 expression levels. Thus, 14‑3‑3σ is a potential prognostic marker for gastric cancer patients, and may be involved in regulating the apoptosis and proliferation of gastric cancer cells.
View Figures
View References

Related Articles

Journal Cover

January-2015
Volume 9 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li YL, Liu L, Xiao Y, Zeng T and Zeng C: 14‑3‑3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer. Oncol Lett 9: 290-294, 2015
APA
Li, Y., Liu, L., Xiao, Y., Zeng, T., & Zeng, C. (2015). 14‑3‑3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer. Oncology Letters, 9, 290-294. https://doi.org/10.3892/ol.2014.2676
MLA
Li, Y., Liu, L., Xiao, Y., Zeng, T., Zeng, C."14‑3‑3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer". Oncology Letters 9.1 (2015): 290-294.
Chicago
Li, Y., Liu, L., Xiao, Y., Zeng, T., Zeng, C."14‑3‑3σ is an independent prognostic biomarker for gastric cancer and is associated with apoptosis and proliferation in gastric cancer". Oncology Letters 9, no. 1 (2015): 290-294. https://doi.org/10.3892/ol.2014.2676