Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy: A case report

Pasta,Vittorio; Sottile,Daniela; Urciuoli,Paolo; Del Vecchio,Luca; Custureri,Filippo; D'Orazi,Valerio

doi:10.3892/ol.2014.2803

Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy: A case report

Authors:
- Vittorio Pasta
- Daniela Sottile
- Paolo Urciuoli
- Luca Del Vecchio
- Filippo Custureri
- Valerio D'Orazi
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Affiliations: Department of Surgical Sciences, Sapienza University, Rome I‑00161, Italy
Published online on: December 17, 2014 https://doi.org/10.3892/ol.2014.2803
Pages: 1116-1120
Copyright: © Pasta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast chondrosarcoma is a rare sarcoma that mainly occurs in females >50 years old. To the best of our knowledge, only 16 cases were reported in the literature prior to 2013 and all patients were surgically treated by mastectomy, with or without lymphadenectomy, which was occasionally preceded by neoadjuvant chemotherapy. However, the literature does not report the benefit of mastectomy compared with a more conservative surgery. The present study reports a novel case of extraskeletal chondrosarcoma of the breast. A 63‑year‑old female patient presented with a neoplasm localized in the upper‑outer quadrant of the right breast. The palpable lesion with sharp margins was a firm parenchymatous mass, which was confirmed by ultrasonography and mammography. The patient underwent conservative quadrantectomy instead of mastectomy, followed by post‑surgical chemotherapy. A positron emission tomography scan performed five months subsequent to the surgery revealed no remnants of the disease. The patient underwent a strict clinical and instrumental follow‑up, and two and half years after surgery, there are no signs of recurrent disease. In conclusion, the present case is currently one of the two cases in which a more conservative quadrantectomy was performed, instead of mastectomy. This surgical approach did not lead to metastasis and resulted in a good follow‑up for the patient.

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1	Lewin J, Puri A, Quek R, Ngan R, Alcasabas AP, Wood D and Thomas D: Management of sarcoma in the Asia-Pacific region: resource-stratified guidelines. Lancet Oncol. 14:e562–e570. 2013. View Article : Google Scholar : PubMed/NCBI
2	Demetri GD, Antonia S, Benjamin RS, et al: National Comprehensive Cancer Network Soft Tissue Sarcoma Panel: Soft tissue sarcoma. J Natl Compr Canc Netw. 8:630–674. 2010.PubMed/NCBI
3	Kennedy T and Biggart JD: Sarcoma of the breast. Br J Cancer. 21:635–644. 1967. View Article : Google Scholar : PubMed/NCBI
4	Beltaos E and Banerjee TK: Chondrosarcoma of the breast: Report of two cases. Am J Clin Pathol. 71:345–349. 1979.PubMed/NCBI
5	Thilagavathi G, Subramanian S, Samuel AV, Rani U and Somasundaram C: Primary chondrosarcoma of the breast. J Indian Med Assoc. 90:16–17. 1992.PubMed/NCBI
6	Guymar S, Ferlicot S, Genestie C, Gelberg JJ, Blondon J, Le Charpentier Y and Zafrani B: Breast chondrosarcoma: a case report and review. Ann Pathol. 21:168–171. 2001.(In French). PubMed/NCBI
7	Errarhay S, Fetohi M, Mahmoud S, et al: Primary chondrosarcoma of the breast: a case presentation and review of the literature. World J Surg. 11:2082013. View Article : Google Scholar
8	Badyal RK, Kataria AS and Kaur M: Primary chondrosarcoma of male breast: a rare case. Indian J Surg. 74:418–419. 2012. View Article : Google Scholar :
9	Gupta S, Gupta V, Aggarwal PN, Kant R, Khurana N and Mandal AK: Primary chondrosarcoma of the breast: a case report. Indian J Cancer. 40:77–79. 2003.
10	Gupta S, Gupta V, Aggarwal PN, Kant R, Dass PM, Khurana N and Mandal AK: Primary chondrosarcoma of the breast. J Indian Med Assoc. 104:99–100. 2006.PubMed/NCBI
11	De Padua M and Bhandari TP: Primary mesenchymal chondrosarcoma of the breast. Indian J Pathol Microbiol. 52:129–130. 2009. View Article : Google Scholar : PubMed/NCBI
12	Patterson JD, Wilson JE, Dim D and Talboy GE: Primary chondrosarcoma of the breast: report of a case and review of the literature. Breast Dis. 33:189–191. 2011.PubMed/NCBI
13	Mujtaba SS, Haroon S and Faridi N: Primary chondrosarcoma of breast. J Coll Physicians Surg Pak. 23:754–755. 2013.PubMed/NCBI
14	Lakshmikantha A, Kawatra V, Varma D and Khurana N: Primary breast chondrosarcoma. Breast J. 16:553–554. 2010. View Article : Google Scholar : PubMed/NCBI
15	Bhosale SJ, Kshirsagar AY, Sulhyan SR, et al: Metaplastic carcinoma with predominant chondrosarcoma of the right breast. Case Rep Oncol. 3:277–281. 2010. View Article : Google Scholar
16	Gurleyik E, Yildirim U, Gunai O and Pehlivan M: Malignant mesenchymal tumor of the breast: primary chondrosarcoma. Breast Care (Basel). 4:101–103. 2009. View Article : Google Scholar
17	Verfaillie G, Breucq C, Perdaens C, et al: Chondrosarcoma of the breast. Breast J. 11:147–148. 2005. View Article : Google Scholar : PubMed/NCBI
18	Rao L, Kudva R, Rao RV and Kumar B: Extraskeletal myxoid chondrosarcoma of the chest wall masquerading as a breast tumor. A case report. Acta Cytol. 46:417–421. 2002. View Article : Google Scholar : PubMed/NCBI
19	Vera-Sempere F and García-Martínez A: Malignant phyllodes tumor of the breast with predominant chondrosarcomatous differentiation. Pathol Res Pract. 199:841–845. 2003. View Article : Google Scholar
20	Pencavel TD and Hayes A: Breast sarcoma - a review of diagnosis and management. Int J Surg. 7:20–23. 2009. View Article : Google Scholar
21	Rakha EA, Tan PH, Shaaban A, et al: Do primary mammary osteosarcoma and chondrosarcoma exist? A review of a large multi-institutional series of malignant matrix-producing breast tumours. Breast. 22:13–18. 2013. View Article : Google Scholar
22	Zelek L, Llombart-Cussac A, Terrier P, et al: Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 21:2583–2588. 2003. View Article : Google Scholar : PubMed/NCBI
23	Pasta V, Monti M, Antonucci D, Di Matteo FM, Boccaccini F and Brescia A: Primary sarcoma of the breast: criteria for radical surgery. G Chir. 18:703–706. 1997.(In Italian).
24	Baldini EH, Goldberg J, Jenner C, Manola JB, Demetri GD, Fletcher CD and Singer S: Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk. J Clin Oncol. 17:3252–3259. 1999.PubMed/NCBI
25	Stojadinovic A, Leung DH, Hoos A, Jaques DP, Lewis JJ and Brennan MF: Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg. 235:424–434. 2002. View Article : Google Scholar : PubMed/NCBI
26	Faraht A, Magdy N and Elaffandi A: Primary myxoid chondrosarcoma of the breast. Ann R Coll Surg Engl. 96:112E–411E. 2014. View Article : Google Scholar