CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia

  • Authors:
    • Jinlin Liu
    • Yonglie Zhou
    • Qiang Huang
    • Liannv Qiu
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  • Published online on: December 17, 2014     https://doi.org/10.3892/ol.2014.2808
  • Pages: 1167-1172
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Abstract

Currently, no prognostic factors exist for determining the host immune status of chronic lymphocytic leukemia (CLL) patients. Therefore, the present report analyzed cluster of differentiation 14 (CD14)+ human leukocyte antigen (HLA)‑DRlow/‑ myeloid‑derived suppressor cells (MDSC) from 49 CLL patients and demonstrated that these cells were significantly expanded in all CLL patients when compared with monoclonal B cell lymphocytosis patients and healthy volunteers. Furthermore, upregulation of CD14+HLA‑DRlow/‑ MDSCs was correlated with CLL tumor progression and a poor prognosis for CLL patients, and CD14+HLA‑DRlow/‑ MDSCs were significantly correlated with the presence of CD4+ T and CD5+CD19+ cells in CLL patients, which could significantly inhibit the CD4+ T‑cell immune response, contributing to CLL cell progression in CLL patients.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu J, Zhou Y, Huang Q and Qiu L: CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia. Oncol Lett 9: 1167-1172, 2015
APA
Liu, J., Zhou, Y., Huang, Q., & Qiu, L. (2015). CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia. Oncology Letters, 9, 1167-1172. https://doi.org/10.3892/ol.2014.2808
MLA
Liu, J., Zhou, Y., Huang, Q., Qiu, L."CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia". Oncology Letters 9.3 (2015): 1167-1172.
Chicago
Liu, J., Zhou, Y., Huang, Q., Qiu, L."CD14+HLA-DRlow/‑ expression: A novel prognostic factor in chronic lymphocytic leukemia". Oncology Letters 9, no. 3 (2015): 1167-1172. https://doi.org/10.3892/ol.2014.2808