Treatment for giant cell tumor of the spine metastasizing to the lung: A report of two cases and a literature review

Muheremu,Aikeremujiang; Huang,Zhen; Niu,Xiaohui

doi:10.3892/ol.2014.2837

Treatment for giant cell tumor of the spine metastasizing to the lung: A report of two cases and a literature review

Authors:
- Aikeremujiang Muheremu
- Zhen Huang
- Xiaohui Niu
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Affiliations: Department of Orthopedic Oncology Surgery, Beijing Jishuitan Hospital, Beijing 100035, P.R. China
Published online on: December 30, 2014 https://doi.org/10.3892/ol.2014.2837
Pages: 1321-1326

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Abstract

Giant cell tumors of the bone (GCTB) account for 5% of all primary skeletal tumors. Although the tumors are normally benign, recurrence and metastasis of GCTB does occur. The most usual sites of a primary GCTB lesion are the distal femur and proximal tibia, and ~3% of these metastasize to the lung. Primary GCTB lesions in the spine are rare, and there have been few cases reporting the pulmonary metastasis of GCTB in the spine. The present study reports two cases of thoracic and sacral spinal GCTB lesions with pulmonary metastasis. One of the patients was a 45‑year‑old male who presented to hospital with gradually worsening pain in the left buttock during the last two years and was diagnosed with GCTB of the sacrum. The other patient was a 30‑year‑old female who complained of persistent back pain for a year and was also diagnosed with GCTB of the sacrum. Arterial embolization was performed prior to surgery and computer navigation was used during the surgery, resulting in the two patients achieving en bloc resection of their respective tumors, with satisfactory rehabilitation to follow.

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