Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report

Iovino,Francesco; Orditura,Michele; Auriemma,Pasquale  Pio; Ciorra,Francesca  Romana; Giordano,Giovanni; Orabona,Consiglia; Bara,Francesco; Sergio,Renato; Savastano,Beatrice; Fabozzi,Alessio; Laterza,Maria  Maddalena; Ventriglia,Jole; Petrillo,Angelica; Della Corte,Carminia   Maria; De Vita,Ferdinando

doi:10.3892/ol.2014.2822

Vertebral carcinomatosis eleven years after advanced gastric cancer resection: A case report

Authors:
- Francesco Iovino
- Michele Orditura
- Pasquale Pio Auriemma
- Francesca Romana Ciorra
- Giovanni Giordano
- Consiglia Orabona
- Francesco Bara
- Renato Sergio
- Beatrice Savastano
- Alessio Fabozzi
- Maria Maddalena Laterza
- Jole Ventriglia
- Angelica Petrillo
- Carminia Maria Della Corte
- Ferdinando De Vita
View Affiliations

Affiliations: IX Division of General Surgery, Department of Anaesthetic, Surgical and Emergency Sciences, Second University of Naples, Naples I‑80131, Italy, Division of Medical Oncology, ‘F. Magrassi ‑ A. Lanzara’ Department of Clinical and Experimental Medicine, Second University of Naples School of Medicine, Naples I‑80131, Italy
Published online on: December 23, 2014 https://doi.org/10.3892/ol.2014.2822
Pages: 1403-1405

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Bone metastasis is an uncommon event in advanced gastric cancer patients and bone metastases are rarely detected as isolated lesions. However, eleven years after treatment for locally advanced gastric cancer, including total gastrectomy followed by adjuvant chemotherapy, a 49‑year‑old female was admitted to the IX Division of General Surgery of the Second University of Naples (Naples, Italy) exhibiting severe progressive neurological symptoms. Magnetic resonance imaging indicated vertebral abnormalities, with evidence of marrow infiltration in several vertebral bodies; however, a contrast‑enhanced computed tomography scan did not detect disease progression to other sites. Biopsy of the soft tissue at the level of the second lumbar vertebra (L2) revealed a metastatic lesion derived from gastric mucinous adenocarcinoma. The patient was initially treated with radiotherapy directed to the L2‑L4 vertebral bodies to control the pain. Subsequently, systemic chemotherapy according to a FOLFOX‑4 (leucovorin, fluorouracil and oxaliplatin) regimen commenced. However, after eight cycles, pulmonary progression of the disease occurred. Thus, palliative care was administered and the patient succumbed one month later. The late relapse of gastric cancer in the current patient may be associated with the theory of tumour dormancy.

View Figures

View References

1	Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statics. CA Cancer J Clin. 61:1342011. View Article : Google Scholar
2	Lehnert T, Rudek B, Buhl K and Golling M: Surgical therapy for loco-regional recurrence and distant metastasis of gastric cancer. Eur J Surg Oncol. 28:455–461. 2002. View Article : Google Scholar : PubMed/NCBI
3	Park JM, Song KY, O JH, et al: Bone recurrence after curative resection of gastric cancer. Gastric Cancer. 16:362–369. 2013. View Article : Google Scholar
4	Shiraishi N, Inomata M, Osawa N, et al: Early and late recurrence after gastrectomy of gastric carcinoma. Univariate and multivariate analyses. Cancer. 89:255–261. 2000. View Article : Google Scholar : PubMed/NCBI
5	Song KY, Park SM, Kim SN and Park CH: The role of surgery in the treatment of recurrent gastric cancer. Am J Surg. 196:19–22. 2008. View Article : Google Scholar : PubMed/NCBI
6	Moon YW, Jeung HC, Rha SY, et al: Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: a 15-year follow-up study at a single Korean institute. Ann Surg Oncol. 14:2730–2737. 2007. View Article : Google Scholar : PubMed/NCBI
7	Nishidoi H and Koga S: Clinicopathological study of gastric cancer with bone metastasis. Gan To Kagaku Ryoho. 14:1717–1722. 1987.(In Japanese). PubMed/NCBI
8	Crivellari D, Carbone A, Sigon R, et al: Gastric cancer with bone marrow invasion at presentation: case-report and review of the literature. Tumori. 81:74–76. 1995.PubMed/NCBI
9	Noda N, Sano T, Shirao K, et al: A case of bone marrow recurrence from gastric carcinoma after a nine-year disease-free interval. Jpn J Clin Oncol. 26:472–475. 1996. View Article : Google Scholar : PubMed/NCBI
10	Abrams HL, Spiro R and Goldstein N: Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer. 3:74–85. 1950. View Article : Google Scholar : PubMed/NCBI
11	Sobin LH1 and Fleming ID: TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer. 80:1803–1804. 1997. View Article : Google Scholar : PubMed/NCBI
12	De Vita F, Giuliani F, Orditura M, et al: Adjuvant chemotherapy with epirubicin, leucovorin, 5-fluorouracil and etoposide regimen in resected gastric cancer patients: a randomized phase III trial by the Gruppo Oncologico Italia Meridionale (GOIM 9602 Study). Ann Oncol. 18:1354–1358. 2007. View Article : Google Scholar : PubMed/NCBI
13	De Vita F, Giuliani F, Silvestris N, et al: Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target. Cancer Treat Rev. 3653(Suppl 3): S11–S15. 2010. View Article : Google Scholar
14	Kobayashi M, Okabayashi T, Sano T and Araki K: Metastatic bone cancer as a recurrence of early gastric cancer - characteristics and possible mechanisms. World J Gastroenterol. 11:5587–5591. 2005.PubMed/NCBI
15	Galasko C: The anatomy and pathways of skeletal metastases. Bone Metastases. Weiss L and Gilbert A: GK Hall; Boston, MA: pp. 49–63. 1981
16	Ajani JA, Bentrem DJ, Besh S, et al; National Comprehensive Cancer Network. Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines. J Natl Compr Canc Netw. 11:531–546. 2013.PubMed/NCBI
17	Field K, Michael M and Leong T: Locally advanced and metastatic gastric cancer: current management and new treatment developments. Drugs. 68:299–317. 2008. View Article : Google Scholar : PubMed/NCBI
18	Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar : PubMed/NCBI
19	Feng XY, Chen YB, Wang W, et al: Time-varying pattern of recurrence risk for gastric cancer patients. Med Oncol. 30:5142013. View Article : Google Scholar : PubMed/NCBI
20	Blanchette P, Lipton JH, Barth D and Mackay H: Case report of very late gastric cancer recurrence. Curr Oncol. 20:e161–e164. 2013. View Article : Google Scholar : PubMed/NCBI
21	Willis RA: Secondary tumors of bones. The spread of tumors in the human body. 3rd edition. Butterworth-Heinemann; London: pp. 229–250. 1973
22	Yoshikawa K and Kitaoka H: Bone metastasis of gastric cancer. Jpn J Surg. 13:173–176. 1983. View Article : Google Scholar : PubMed/NCBI
23	Turkoz FP, Solak M, Kilickap S, et al: Bone metastasis from gastric cancer: the incidence, clinicopathological features, and influence on survival. J Gastric Cancer. 14:164–172. 2014. View Article : Google Scholar : PubMed/NCBI
24	Naumov GN, MacDonald IC, Weinmeister PM, et al: Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res. 62:2162–2168. 2002.PubMed/NCBI
25	Naumov GN, MacDonald IC, Chambers AF and Groom AC: Solitary cancer cells as a possible source of tumour dormancy? Semin Cancer Biol. 11:271–276. 2001. View Article : Google Scholar : PubMed/NCBI