Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER‑2‑overexpressing breast cancer

  • Authors:
    • Weicai Chen
    • Jinsong He
    • Shufen Song
    • Min Wang
    • Huisheng Wu
    • Xianming Wang
  • View Affiliations

  • Published online on: January 28, 2015     https://doi.org/10.3892/ol.2015.2912
  • Pages: 1922-1926
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Abstract

The aim of the present study was to observe the efficacy of neoadjuvant trastuzumab combined with docetaxel and carboplatin (tch), and docetaxel, epirubicin and cyclophosphamide (tEc) chemotherapy in human epidermal growth factor receptor‑2 (her‑2)‑overexpressing breast cancer. The total cohort of 64 cases of her‑2‑overexpressing breast cancer patients was divided into two groups according to their treatment preferences: The tch group, consisting of 39 patients, and the tEc group, consisting of 25 patients. the neoadjuvant chemotherapy was continued for six cycles prior to comparison of the treatment efficacy. the TCG and TEC groups exhibited an overall response rate of 94.9 and 72.0% (37/39 and 18/25 cases; P<0.05), respectively, and a pathological complete response (pCR; defined as the presence of no invasive or in situ residual tumors in the breast) rate of 69.2 and 32.0% (27/39 and 8/25 cases; P<0.05), respectively. Furthermore, no significant differences were identified between the two groups of patients in terms of adverse reactions, such as cardiac dysfunction, bone marrow suppression and liver function impairment. In the present study, the treatment of her‑2‑overexpressing breast cancer patients with TCH neoadjuvant chemotherapy demonstrated more favorable efficacy and a higher pcr rate when compared with the TEC‑treated group.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen W, He J, Song S, Wang M, Wu H and Wang X: Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER‑2‑overexpressing breast cancer. Oncol Lett 9: 1922-1926, 2015
APA
Chen, W., He, J., Song, S., Wang, M., Wu, H., & Wang, X. (2015). Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER‑2‑overexpressing breast cancer. Oncology Letters, 9, 1922-1926. https://doi.org/10.3892/ol.2015.2912
MLA
Chen, W., He, J., Song, S., Wang, M., Wu, H., Wang, X."Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER‑2‑overexpressing breast cancer". Oncology Letters 9.4 (2015): 1922-1926.
Chicago
Chen, W., He, J., Song, S., Wang, M., Wu, H., Wang, X."Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER‑2‑overexpressing breast cancer". Oncology Letters 9, no. 4 (2015): 1922-1926. https://doi.org/10.3892/ol.2015.2912