Renal-type clear cell carcinoma of the prostate: A case report

Wang,Qiulan; Xue,Yongjie

doi:10.3892/ol.2015.3062

Renal-type clear cell carcinoma of the prostate: A case report

Authors:
- Qiulan Wang
- Yongjie Xue
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Affiliations: Clinical College, Gansu University of Chinese Traditional Medicine, Lanzhou, Gansu 730000, P.R. China, Department of Pathology, San Ai Tang Hospital, Lanzhou, Gansu 730030, P.R. China
Published online on: March 20, 2015 https://doi.org/10.3892/ol.2015.3062
Pages: 2149-2152

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Abstract

Renal-type clear cell carcinoma of the prostate is a rare and novel tumor that has only been identified in recent years. The present study describes a lesion in the prostate of a 64‑year‑old male with a two‑year history of urinary frequency, urgency and difficulty, who was admitted to the San Ai Tang Hospital for benign prostatic hyperplasia, and subsequently underwent transurethral resection of the prostate. In total, 12 g of tissue was resected, which demonstrated morphological and immunohistochemical similarities to clear cell carcinoma of the kidney. Ultrasound inspection and computed tomography revealed prostate enlargement. Although no renal‑enclosed mass was identified, metastatic lesions were revealed in the lungs, sternum and clavicles. In addition, right pleural thickening and a small amount of effusion in the pleural cavity were detected. Clear cell carcinoma was identified throughout the prostate, with surrounding regions of ordinary‑type prostatic adenocarcinoma (Gleason score, 4+4). The urinary bladder exhibited no dysplasia or neoplasia. It was therefore concluded that the tumor represented a primary renal‑type clear cell carcinoma that had arisen in the prostate. To the best of our knowledge, this type of extra-renal tumor has only been reported in three other previous studies.

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1	Pan CC, Chiang H, Chang YH and Epstein JI: Tubulocystic clear cell adenocarcinoma arising within the prostate. Am J Surg Pathol. 24:1433–1436. 2000. View Article : Google Scholar : PubMed/NCBI
2	Humphrey PA: Clear cell neoplasms of the urinary tract and male reproductive system. Semin Diagn Pathol. 14:240–252. 1997.PubMed/NCBI
3	Eble JN, Sauter G, Epstein JI and Sesterhenn IA: Pathology and Genetics of Tumours of the Urinary System and Male Genital OrgansIn: World Health Organization Classification of Tumours. IARC Press; Lyon: pp. 4–19. 2004
4	Ljungberg B, Cowan NC, Hanbury DC, et al: European Association of Urology Guideline Group: EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol. 58:398–406. 2010. View Article : Google Scholar : PubMed/NCBI
5	Ritchie AW and Chisholm GD: The natural history of renal carcinoma. Semin Oncol. 10:390–400. 1983.PubMed/NCBI
6	Flanigan RC, Campbell SC, Clark JI and Picken MM: Metastatic renal cell carcinoma. Curr Treat Options Oncol. 4:385–390. 2003. View Article : Google Scholar : PubMed/NCBI
7	Cihak RW, Haas R Jr, Koenen CT and Chinchinian H: Metastatic renal carcinoma to the prostate gland: presentation as prostatic hypertrophy. J Urol. 123:791–792. 1980.PubMed/NCBI
8	King DH, Centeno AS, Saldivar VA and Sarosdy MF: Renal cell carcinoma metastatic to the gallbladder or prostate: two case reports. Urology. 46:722–725. 1995. View Article : Google Scholar : PubMed/NCBI
9	Ferlay J, Soerjomataram I, Ervik M, et al: Cancer incidence and mortality worldwide: Sources, methodsand major patterns in GLOBOCAN 2012. Int J Cancer. 136:359–386. 2014. View Article : Google Scholar
10	Wang H and Yang H: The recent advances in the treatment of renal clear cell carcinoma of internal and adverse drug reactions. Chinese Journal of Medicine. 41:11–14. 2006.
11	Singh H, Flores-Sandoval N and Abrams J: Renal-type clear cell carcinoma occurring in the prostate. Am J Surg Patho. 27:407–410. 2003. View Article : Google Scholar
12	Pal DK and Chowdhury MK: Renal type clear cell carcinoma of prostate. Indian J Surg. 69:812007.
13	Permi HS, Laxminarayana KP, Yeshvanth SK and Shetty JK: Renal type clear cell carcinoma of the prostate: a diagnostic dilemma. J Lab Physicians. 3:132–133. 2011. View Article : Google Scholar : PubMed/NCBI
14	Epstein JI, Allsbrook WC Jr, Amin MB and Egevad LL: ISUP Grading Committee: The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol. 29:1228–1242. 2005. View Article : Google Scholar : PubMed/NCBI
15	Allan CH and Epstein JI: Nephrogenic adenoma of the prostatic urethra: a mimicker of prostate adenocarcinoma. Am J Surg Pathol. 25:80–808. 2001. View Article : Google Scholar : PubMed/NCBI
16	Gilcrease MZ, Delgrado R, Vuitch F and Albores-Saavedra J: Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison. Hum Pathol. 29:1451–1456. 1998. View Article : Google Scholar : PubMed/NCBI
17	Alsanjari N, Lynch MJ, Fisher C and Parkinson MC: Vesical clear cell adenocarcinoma. V. Nephrogenic adenoma: a diagnostic problem. Histopathology. 27:43–49. 1995. View Article : Google Scholar : PubMed/NCBI
18	Malpica A, Ro JY, Troncoso P, et al: Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. Hum Pathol. 25:390–395. 1994. View Article : Google Scholar : PubMed/NCBI