Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)

Zhang,Zhifen; Zou,Jianwen; Li,Yuantang; Liu,Zhanfeng; Xu,Rui; Tian,Wenjun; Zhao,Zongchen; Sun,Hui; Han,Jingying; Wang,Jia; Zhang,Bingchang; Ju,Ying

doi:10.3892/ol.2015.3051

Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22)

Authors:
- Zhifen Zhang
- Jianwen Zou
- Yuantang Li
- Zhanfeng Liu
- Rui Xu
- Wenjun Tian
- Zongchen Zhao
- Hui Sun
- Jingying Han
- Jia Wang
- Bingchang Zhang
- Ying Ju
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Affiliations: Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
Published online on: March 17, 2015 https://doi.org/10.3892/ol.2015.3051
Pages: 2244-2248

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Abstract

The present study reviewed three patients with acute myeloid leukemia (AML) who had the specific genetic abnormality t(16;21)(p11;q22). To investigate the clinical and laboratory characteristics of AML with t(16;21)(p11;q22) translocation, the similarities and differences of clinical characteristics and laboratory examinations were compared, and a literature review was conducted. According to the French‑American‑British classification system, patient 1 was M4, patient 2 was M1 and patient 3 was M2. The cytogenetic aberrations were 46, XY, t(16;21)(p11;q22)/47, idem, +21 for patient 1 and 46, XX, t(16;21)(p11;q22) for patients 2 and 3. Cytophagocytosis and cluster of differentiation 56 antigen expression were found in all three cases. The prognosis was poor in all the cases. AML with t(16;21)(p11;q22) is a specific subtype of AML that exhibits unique characteristics of morphology, immunology, cytogenetics and clinical features, as well as a poor prognosis. Stem cell transplantation may be the first and only choice for treatment.

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