High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats

Xia,Hui; Zhang,Wen; Li,Yingjie; Yu,Changhai

doi:10.3892/ol.2015.2989

High performance liquid chromatography: Tandem mass spectrometric determination of cisplatin levels in different visceral pleura layers of rats

Authors:
- Hui Xia
- Wen Zhang
- Yingjie Li
- Changhai Yu
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Affiliations: Department of Thoracic‑Cardio Surgery, First Affiliated Hospital of PLA General Hospital, Beijing 100048, P.R. China
Published online on: February 26, 2015 https://doi.org/10.3892/ol.2015.2989
Pages: 2388-2392

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Abstract

The aim of the present study was to investigate the concentration of cisplatin in different layers of the visceral pleura in rats, following drug administration. In this study, a sensitive and specific liquid chromatography method coupled with electrospray ionization‑tandem mass spectrometry was established to investigate the disposition of cisplatin in different layers of the visceral pleura in rats. Methodological data, including specificity, linearity, accuracy, recovery, precision and lower limits of quantification, confirmed that this novel method may be used to efficiently quantify the cisplatin concentrations in visceral pleura of rats following administration of the drug. Furthermore, the results demonstrated that the desired drug concentration was not achieved in the outer or inner elastic layers of the visceral pleura following injection with cisplatin through various administration methods.

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1	Hinojosa de la Garza OR, Sanín LH, Montero Cabrera ME, et al: Lung cancer mortality and radon concentration in a chronically exposed neighborhood in Chihuahua, Mexico: a geospatial analysis. Scientific World Journal. 2014:9353802014. View Article : Google Scholar : PubMed/NCBI
2	Torre LA, Bray F, Siegel RL, et al: Global cancer statistics. 2012. CA Cancer J Clin. Feb 4–2015.(Epub ahead of print).
3	Fidias P and Novello S: Strategies for prolonged therapy in patients with advanced non-small-cell lung cancer. J Clin Oncol. 28:5116–5123. 2010. View Article : Google Scholar : PubMed/NCBI
4	Cohen MH, Cortazar P, Justice R and Pazdur R: Approval summary: Pemetrexed maintenance therapy of advanced/metastatic nonsquamous, non-small cell lung cancer (NSCLC). Oncologist. 15:1352–1358. 2010. View Article : Google Scholar : PubMed/NCBI
5	Bareschino MA, Schettino C, Rossi A, et al: Treatment of advanced non small cell lung cancer. J Thorac Dis. 3:122–133. 2011.PubMed/NCBI
6	Leighl NB: Treatment paradigms for patients with metastatic non-small-cell lung cancer: First-, second-, and third-line. Curr Oncol. 19:S52–S58. 2012. View Article : Google Scholar : PubMed/NCBI
7	Sangha R, Price J and Butts CA: Adjuvant therapy in non-small cell lung cancer: Current and future directions. Oncologist. 15:862–872. 2010. View Article : Google Scholar : PubMed/NCBI
8	Ost D, Goldberg J, Rolnitzky L and Rom WN: Survival after surgery in stage IA and IB non-small cell lung cancer. Am J Respir Crit Care Med. 177:516–523. 2008. View Article : Google Scholar : PubMed/NCBI
9	Riquet M, Arame A and Mordant P: Visceral pleural invasion: a prognostic factor beginning with small size and increasing with the progression of lung cancer. Ann Thorac Surg. 97:3832014. View Article : Google Scholar : PubMed/NCBI
10	van Meerbeeck JP and Janssens A: The seventh tumour-node-metastasis staging system for lung cancer: Sequel or prequel? Europ J Cancer. Suppl 11:150–158. 2013. View Article : Google Scholar
11	Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar : PubMed/NCBI
12	Cho S, Park TI, Lee EB and Son SA: Poor Prognostic Factors in Surgically Resected Stage I Non-small Cell Lung Cancer: Histopathologic and Immunohistochemical Analysis. Korean J Thorac Cardiovasc Surg. 45:101–109. 2012. View Article : Google Scholar : PubMed/NCBI
13	Park SY, Lee JG, Kim J, et al: Efficacy of platinum-based adjuvant chemotherapy in T2aN0 stage IB non-small cell lung cancer. J Cardiothorac Surg. 8:1512013. View Article : Google Scholar : PubMed/NCBI
14	Kawase A, Yoshida J, Miyaoka E, et al: Visceral pleural invasion classification in non-small-cell lung cancer in the 7th edition of the tumor, node, metastasis classification for lung cancer: validation analysis based on a large-scale nationwide database. J Thorac Oncol. 8:606–611. 2013.PubMed/NCBI
15	Hattori A, Suzuki K, Matsunaga T, et al: Visceral pleural invasion is not a significant prognostic factor in patients with a part-solid lung cancer. Ann Thorac Surg. 98:433–438. 2014. View Article : Google Scholar : PubMed/NCBI
16	O'Byrne KJ, Barr MP and Gray SG: The role of epigenetics in resistance to Cisplatin chemotherapy in lung cancer. Cancers Basel. 3:1426–1453. 2011. View Article : Google Scholar : PubMed/NCBI
17	Wangpaichitr M, Wu C, You M, et al: N', N'-Dimethyl-N', N'-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS). Cancers Basel. 1:23–38. 2009. View Article : Google Scholar : PubMed/NCBI
18	Wu XX and Kakehi Y: Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by Cisplatin in caspase-dependent manner. Clin Cancer Res. 15:2039–2047. 2009. View Article : Google Scholar : PubMed/NCBI
19	Sanborn RE: Cisplatin versus carboplatin in NSCLC: Is there one “best” answer. Curr Treat Options Oncol. 9:326–342. 2008. View Article : Google Scholar : PubMed/NCBI
20	Chang A: Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer. 71:3–10. 2011. View Article : Google Scholar : PubMed/NCBI
21	Mudiam MK, Chauhan A, Jain R, et al: Molecularly imprinted polymer coupled with dispersive liquid-liquid microextraction and injector port silylation: a novel approach for the determination of 3-phenoxybenzoic acid in complex biological samples using gas chromatographytandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 945–946:23–30. 2014. View Article : Google Scholar
22	Hoofnagle AN and Roth MY: Clinical review: Improving the measurement of serum thyroglobulin with mass spectrometry. J Clin Endocrinol Metab. 98:1343–1352. 2013. View Article : Google Scholar : PubMed/NCBI
23	Gosetti F, Mazzucco E, Gennaro MC and Marengo E: Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review. J Chromatogr B Analyt Technol Biomed Life Sci. 927:22–36. 2013. View Article : Google Scholar : PubMed/NCBI
24	Gouveia MJ, Brindley PJ, Santos LL, et al: Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: A review. Metabolism. 62:1206–1217. 2013. View Article : Google Scholar : PubMed/NCBI
25	Bielawski J, Szulc ZM, Hannun YA and Bielawska A: Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatographytandem mass spectrometry. Methods. 39:82–91. 2006. View Article : Google Scholar : PubMed/NCBI
26	Liu X, Teng Z, Zhang Y, et al: High performance liquid chromatographytandem mass spectrometric determination of resveratrol and its metabolites in rat tissues. Anal Lett. 43:557–569. 2010. View Article : Google Scholar
27	Chow TW, Szeitz A, Rurak DW and Riggs KW: A validated enantioselective assay for the simultaneous quantitation of (R)-, (S)-fluoxetine and (R)-, (S)-norfluoxetine in ovine plasma using liquid chromatography with tandem mass spectrometry (LC/MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 879:349–358. 2011. View Article : Google Scholar : PubMed/NCBI
28	Nordberg H, Jerndal G and Thompson RA: Direct injection of lipophilic compounds in the organic phase from liquid-liquid extracted plasma samples onto a reversed-phase column. Bioanalysis. 3:1963–1973. 2011. View Article : Google Scholar : PubMed/NCBI
29	Haam SJ, Park IK, Paik HC, et al: T-stage of non-small cell lung cancer directly invading an adjacent lobe. Eur J Cardiothorac Surg. 42:807–810. 2012. View Article : Google Scholar : PubMed/NCBI
30	Torii I, Hashimoto M, Terada T, et al: Well-differentiated papillary mesothelioma with invasion to the chest wall. Lung Cancer. 67:244–247. 2010. View Article : Google Scholar : PubMed/NCBI