XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis

Fan,Jinghua; Fan,Yuhua; Kang,Xiaoxiao; Zhao,Limin

doi:10.3892/ol.2015.3040

XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis

Authors:
- Jinghua Fan
- Yuhua Fan
- Xiaoxiao Kang
- Limin Zhao
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Affiliations: Department of Dermatology, Xi'an Central Hospital, Medical School of Xi'an Jiaotong University, P.R. China, The First Department of Internal Medicine, The Fifth Hospital of Xi'an, Xi'an, Shaanxi 710003, P.R. China
Published online on: March 16, 2015 https://doi.org/10.3892/ol.2015.3040
Pages: 2425-2429

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Abstract

Although the T241M polymorphism in the X-ray cross‑complementing group 3 (XRCC3) gene has been implicated in the pathogenesis of melanoma, the results have been inconsistent. In this study, a meta‑analysis was performed to assess the association of XRCC3 T241M polymorphism with melanoma. Published literature from PubMed and Embase databases was retrieved. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed‑ or random‑effects models. A total of six case‑control studies containing 2,133 patients and 3,141 controls were enrolled into this meta‑analysis. In a combined analysis, the results revealed no significant association between XRCC3 T241M polymorphism and melanoma risk in the overall population. In the subgroup analysis by ethnicity, no significant associations between the XRCC3 T241M polymorphism and melanoma risk were identified in Caucasians. However, when the analyses were restricted to three larger studies (n>500 cases), a significant association was noted with melanoma (TT vs. MT: OR=1.20, 95% CI=1.04‑1.38; dominant model: OR=0.86, 95% CI=0.75‑0.98). In conclusion, the meta‑analysis results suggest that the XRCC3 T241M polymorphism was associated with risk of melanoma. Further large and well‑designed studies are needed to confirm this conclusion.

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