Modified simultaneous integrated boost radiotherapy for large retroperitoneal malignant tumor: A case report

Nomiya,Takuma; Akamatsu,Hiroko; Harada,Mayumi; Ota,Ibuki; Hagiwara,Yasuhito; Ichikawa,Mayumi; Miwa,Misako; Mizutani,Masaomi; Kato,Tomoyuki; Nagaoka,Akira; Tomita,Yoshihiko; Nemoto,Kenji

doi:10.3892/ol.2015.3095

Modified simultaneous integrated boost radiotherapy for large retroperitoneal malignant tumor: A case report

Authors:
- Takuma Nomiya
- Hiroko Akamatsu
- Mayumi Harada
- Ibuki Ota
- Yasuhito Hagiwara
- Mayumi Ichikawa
- Misako Miwa
- Masaomi Mizutani
- Tomoyuki Kato
- Akira Nagaoka
- Yoshihiko Tomita
- Kenji Nemoto
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Affiliations: National Institute of Radiological Sciences, Research Center Hospital for Charged Particle Therapy, Chiba 263‑8555, Japan, Department of Radiation Oncology, Yamagata University Hospital, Yamagata 990‑9585, Japan, Department of Surgery, Yamagata University Hospital, Yamagata 990‑9585, Japan, Department of Urology, Yamagata University Hospital, Yamagata 990‑9585, Japan
Published online on: April 2, 2015 https://doi.org/10.3892/ol.2015.3095
Pages: 2520-2524
Copyright: © Nomiya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current study reports the case of a large retroperitoneal tumor treated with modified simultaneous integrated boost (SIB) radiotherapy. A 45‑year‑old female presented to the emergency department complaining of left abdominal pain and fever. A computed tomography scan detected a retroperitoneal tumor of 12x16x16 cm, and a biopsy revealed a poorly‑differentiated adenocarcinoma. The patient was diagnosed with a large adenocarcinoma originating from the left ureter, with no distant metastasis. Due to the patient's poor physical condition, surgery was not recommended, and the patient was referred to the Department of Radiation Oncology (Yamagata University Hospital, Yamagata, Japan). Modified SIB radiotherapy was administered following the acquisition of written consent from the patient. The total irradiation dose to the center of the tumor and to the surrounding healthy tissue was ~96 Gy/33 fractions and <60 Gy/33 fractions, respectively. At the end of the radiotherapeutic course, the tumor volume was reduced by ≥80%, and the residual tumor was surgically resected. As a result of the resection, a complete pathological response was confirmed; the patient has been recurrence‑free for >3 years with no complications. Modified SIB radiotherapy may be safely administered, with favorable outcomes. Complete recovery can be achieved with this technique, even in a patient with a large radioresistant tumor.

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