Journal Articles

Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review)

Guanhua Song, Lin Wang, Kehong Bi, Guosheng Jiang

Pages: 2099-2106 Published online on: 10 March 2015

Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review)

Ye-Seul Kim, Kyung-A Hwang, Ryeo-Eun Go, Cho-Won Kim, Kyung-Chul Choi

Pages: 2107-2112 Published online on: 10 March 2015

New insights into the mechanism of F-box proteins in colorectal cancer (Review)

Jian Gong, Jirong Huo

Pages: 2113-2120 Published online on: 27 February 2015

Association of annexin A2 with cancer development (Review)

Xiao-Heng Xu, Wei Pan, Li-Hua Kang, Hui Feng, Yan-Qiu Song

Pages: 2121-2128 Published online on: 05 March 2015
Open Access

Lactotrophs: The new and major source for VEGF secretion and the influence of ECM on rat pituitary function in vitro

Joachim Alfer, Joseph Neulen, Andreas Gaumann

Pages: 2129-2134 Published online on: 13 March 2015
Open Access

Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts

Hiroshi Tsukihara, Fumio Nakagawa, Kazuki Sakamoto, Keiji Ishida, Nozomu Tanaka, Hiroyuki Okabe, Junji Uchida, Kenichi Matsuo, Teiji Takechi

Pages: 2135-2142 Published online on: 23 March 2015
Open Access

Synergy of BID with doxorubicin in the killing of cancer cells

Emilia Joanna Orzechowska, Agnieszka Girstun, Krzysztof Staron, Joanna Trzcinska-Danielewicz

Pages: 2143-2150 Published online on: 09 March 2015
Open Access

Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan

Takeyuki Sawano, Takeshi Shimizu, Toshiyuki Yamada, Naoki Nanashima, Takuya Miura, Satoko Morohashi, Daisuke Kudo, Feng Mao Hui, Hiroshi Kijima, Kenichi Hakamada, Shigeki Tsuchida

Pages: 2151-2160 Published online on: 20 February 2015
Open Access

Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma

Teppei Jinno, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Takeshi Toyoshima, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura

Pages: 2161-2168 Published online on: 06 March 2015
Open Access

DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: The same outcome of treatment with different doses in sensitive cell lines

Jakub Neradil, Gabriela Pavlasova, Martin Sramek, Michal Kyr, Renata Veselska, Jaroslav Sterba

Pages: 2169-2175 Published online on: 26 February 2015
Open Access

Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients

Yoshihiko Shibayama, Takeshi Kondo, Hiroki Ohya, Shin-Ichi Fujisawa, Takanori Teshima, Ken Iseki

Pages: 2176-2182 Published online on: 06 March 2015

Effect of REG Iα protein on angiogenesis in gastric cancer tissues

Ken Hara, Hirokazu Fukui, Chao Sun, Yoshitaka Kitayama, Hirotsugu Eda, Takahisa Yamasaki, Takashi Kondo, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Takahiro Fujimori, Hiroto Miwa

Pages: 2183-2189 Published online on: 23 March 2015

Paris saponin II inhibits human ovarian cancer cell‑induced angiogenesis by modulating NF-κB signaling

Mei Yang, Juan Zou, Hongmei Zhu, Shanling Liu, He Wang, Peng Bai, Xue Xiao

Pages: 2190-2198 Published online on: 05 March 2015

Epigenetic bivalent marking is permissive to the synergy of HDAC and PARP inhibitors on TXNIP expression in breast cancer cells

Federica Baldan, Catia Mio, Elisa Lavarone, Carla Di Loreto, Fabio Puglisi, Giuseppe Damante, Cinzia Puppin

Pages: 2199-2206 Published online on: 23 March 2015

Differential proteomic profiling of primary and recurrent chordomas

Su Chen, Wei Xu, Jian Jiao, Dongjie Jiang, Jian Liu, Tenghui Chen, Zongmiao Wan, Leqin Xu, Zhenhua Zhou, Jianru Xiao

Pages: 2207-2218 Published online on: 26 February 2015

Two-dimensional gel electrophoresis analysis of the leiomyoma interstitial fluid reveals altered protein expression with a possible involvement in pathogenesis

Blendi Ura, Federica Scrimin, Fabrizio Zanconati, Giorgio Arrigoni, Lorenzo Monasta, Andrea Romano, Rubina Banco, Marina Zweyer, Daniela Milani, Giuseppe Ricci

Pages: 2219-2226 Published online on: 03 March 2015

High level of CFTR expression is associated with tumor aggression and knockdown of CFTR suppresses proliferation of ovarian cancer in vitro and in vivo

Jiao Xu, Min Yong, Jia Li, Xiaojing Dong, Tinghe Yu, Xiao Fu, Lina Hu

Pages: 2227-2234 Published online on: 03 March 2015

Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells

Cristian G. Torres, Araceli Olivares, Caroll Stoore

Pages: 2235-2244 Published online on: 13 March 2015

Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma

Mei Liu, Armando Varela-Ramirez, Jitian Li, Liping Dai, Renato J. Aguilera, Jian-Ying Zhang

Pages: 2245-2252 Published online on: 16 March 2015

LMP-1 induces survivin expression to inhibit cell apoptosis through the NF-κB and PI3K/Akt signaling pathways in nasal NK/T-cell lymphoma

Lu Sun, Yu Zhao, Huaiyin Shi, Chao Ma, Lixin Wei

Pages: 2253-2260 Published online on: 10 March 2015

Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: An in vitro and in vivo study

Lei Yuan, Jun Han, Qingyang Meng, Qiulei Xi, Qiulin Zhuang, Yi Jiang, Yusong Han, Bo Zhang, Jing Fang, Guohao Wu

Pages: 2261-2268 Published online on: 09 March 2015

Anti-metastatic effects of DNA vaccine encoding single‑chain trimer composed of MHC I and vascular endothelial growth factor receptor 2 peptide

Ruiling Chen, Shengchao Wang, Yunliang Yao, Yun Zhou, Chong Zhang, Jie Fang, Dayong Zhang, Lihuang Zhang, Jianping Pan

Pages: 2269-2276 Published online on: 26 February 2015

Mcl-1 downregulation sensitizes glioma to bortezomib-induced apoptosis

Yang Zhang, Xiaobo Zhu, Kun Hou, Jinchuan Zhao, Zhiguo Han, Xiaona Zhang

Pages: 2277-2284 Published online on: 23 March 2015

Knockdown of flotillin-2 impairs the proliferation of breast cancer cells through modulation of Akt/FOXO signaling

Gui'e Xie, Jinlong Li, Jingsong Chen, Xuewei Tang, Shaoqing Wu, Can Liao

Pages: 2285-2290 Published online on: 03 March 2015

The ALDH1+ subpopulation of the human NMFH‑1 cell line exhibits cancer stem-like characteristics

Dejian Li, Tao Zhang, Wenguang Gu, Peng Li, Xiangyang Cheng, Tiejun Tong, Wenbo Wang

Pages: 2291-2298 Published online on: 09 March 2015

HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells

Meiying Ji, Eun Jeoung Lee, Ki Bae Kim, Yangmi Kim, Rohyun Sung, Sang-Jeon Lee, Don Soo Kim, Seon Mee Park

Pages: 2299-2308 Published online on: 23 March 2015

MicroRNA-326 functions as a tumor suppressor in colorectal cancer by targeting the nin one binding protein

Lei Wu, Hui Hui, Li-Juan Wang, Hao Wang, Qiu-Fang Liu, Su-Xia Han

Pages: 2309-2318 Published online on: 06 March 2015

Repression of engrailed 2 inhibits the proliferation and invasion of human bladder cancer in vitro and in vivo

Yunfei Li, Haitao Liu, Caiyong Lai, Zexuan Su, Baoli Heng, Shuangquan Gao

Pages: 2319-2330 Published online on: 17 March 2015

Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death

Uddin Md. Nazim, Jae-Kyo Jeong, Jae-Won Seol, Jin Hur, Seong-Kug Eo, John-Hwa Lee, Sang-Youel Park

Pages: 2331-2336 Published online on: 20 March 2015

Oncogene ATAD2 promotes cell proliferation, invasion and migration in cervical cancer

Le Zheng, Tianren Li, Yi Zhang, Yi Guo, Jihang Yao, Lei Dou, Kejun Guo

Pages: 2337-2344 Published online on: 20 March 2015

Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1α in canine malignant mammary tumors

Marina Gobbe Moschetta, Larissa Bazela Maschio, Bruna Victorasso Jardim-Perassi, Gabriela Bottaro Gelaleti, Juliana Ramos Lopes, Camila Leonel, Naiane Do Nascimento Gonçalves, Lívia Carvalho Ferreira, Gustavo Rodrigues Martins, Thaiz Ferraz Borin, Debora Aparecida Pires De Campos Zuccari

Pages: 2345-2353 Published online on: 16 March 2015

MicroRNA-424 may function as a tumor suppressor in endometrial carcinoma cells by targeting E2F7

Quan Li, Xiang-Mei Qiu, Qing-Han Li, Xiao-Yan Wang, Li Li, Min Xu, Min Dong, Yan-Bing Xiao

Pages: 2354-2360 Published online on: 20 February 2015

Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-11C]isobutyric acid

Atsushi B. Tsuji, Aya Sugyo, Hitomi Sudo, Chie Suzuki, Hidekatsu Wakizaka, Ming-Rong Zhang, Koichi Kato, Tsuneo Saga

Pages: 2361-2367 Published online on: 20 March 2015

Tetramethylpyrazine inhibits the proliferation of acute lymphocytic leukemia cell lines via decrease in GSK-3β

Xiao-Jing Wang, You-Hua Xu, Gui-Cun Yang, Hong-Xia Chen, Ping Zhang

Pages: 2368-2374 Published online on: 18 March 2015

Expression of NEDD9 in hepatocellular carcinoma and its clinical significance

Peng Lu, Zhi-Peng Wang, Zheng Dang, Zhi-Gang Zheng, Xiao Li, Liang Zhou, Rui Ding, Shu-Qiang Yue, Ke-Feng Dou

Pages: 2375-2383 Published online on: 18 March 2015

Ribavirin as a tri-targeted antitumor repositioned drug

Erick De la Cruz-Hernandez, Jose Luis Medina-Franco, Jaenai Trujillo, Alma Chavez-Blanco, Guadalupe Dominguez-Gomez, Enrique Perez-Cardenas, Aurora Gonzalez-Fierro, Lucia Taja-Chayeb, Alfonso Dueñas-Gonzalez

Pages: 2384-2392 Published online on: 25 February 2015

MicroRNA‑494 promotes cervical cancer proliferation through the regulation of PTEN

Yong‑Kang Yang, Wen‑Yan Xi, Ru‑Xing Xi, Jing‑Yuan Li, Qin Li, Yan‑E Gao

Pages: 2393-2401 Published online on: 26 February 2015

Targeting FoxM1 inhibits proliferation, invasion and migration of nasopharyngeal carcinoma through the epithelial‑to-mesenchymal transition pathway

Chao Yu, Lili Chen, Lin Yie, Lei Wei, Taoyu Wen, Yanan Liu, Hongyan Chen

Pages: 2402-2410 Published online on: 04 March 2015

Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1

Ki-Eun Hwang, Young-Suk Kim, Yu-Ri Hwang, Su-Jin Kwon, Do-Sim Park, Byong‑Ki Cha, Byoung-Ryun Kim, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim

Pages: 2411-2419 Published online on: 04 March 2015

Establishment of an expression platform of OATP1B1 388GG and 521CC genetic polymorphism and the therapeutic effect of tamoxifen in MCF-7 cells

Zhichen Pu, Xuefeng Zhang, Qun Chen, Xiaolong Yuan, Haitang Xie

Pages: 2420-2428 Published online on: 18 March 2015

Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway

Yang-Ching Ko, Jin-Cherng Lien, Hsin-Chung Liu, Shu-Chun Hsu, Bin-Chuan Ji, Mei-Due Yang, Wu-Huei Hsu, Jing-Gung Chung

Pages: 2429-2437 Published online on: 18 March 2015

RNA-binding motif protein 5 negatively regulates the activity of Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury

Yu-Qiu Hao, Zhen-Zhong Su, Xue-Jiao Lv, Ping Li, Peng Gao, Chen Wang, Yue Bai, Jie Zhang

Pages: 2438-2444 Published online on: 03 March 2015

Investigation of the roles of exosomes in colorectal cancer liver metastasis

Xia Wang, Xiaoling Ding, Lijuan Nan, Yiting Wang, Jing Wang, Zhiqiang Yan, Wei Zhang, Jihong Sun, Wei Zhu, Bing Ni, Suzhen Dong, Lei Yu

Pages: 2445-2453 Published online on: 09 March 2015

PLU-1/JARID1B overexpression predicts proliferation properties in head and neck squamous cell carcinoma

Zhibin Cui, Liwei Song, Zhaoyuan Hou, Yifan Han, Yuhua Hu, Yadi Wu, Wantao Chen, Li Mao

Pages: 2454-2460 Published online on: 12 March 2015

HBx co-localizes with COXIII in HL-7702 cells to upregulate mitochondrial function and ROS generation

Lai-Yu Zou, Bi-Yun Zheng, Xue-Fen Fang, Dan Li, Yue-Hong Huang, Zhi-Xin Chen, Lin-Ying Zhou, Xiao-Zhong Wang

Pages: 2461-2467 Published online on: 13 March 2015

Lentiviral vector-mediated doxycycline-inducible USP39 shRNA or cDNA expression in triple-negative breast cancer cells

Shihai Liu, Xiangping Liu, Haibo Wang, Quan Zhou, Ye Liang, Aihua Sui, Ruyong Yao, Bin Zhao, Ming Sun

Pages: 2477-2483 Published online on: 20 March 2015

Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches

Bo Su, Jian Su, Hui He, Youhua Wu, Hong Xia, Xi Zeng, Wenxiang Dai, Xiaohong Ai, Hui Ling, Hao Jiang, Qi Su

Pages: 2484-2494 Published online on: 17 March 2015

Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2

Wenjuan Wu, Xizhi Zhang, Haonan Qin, Wanxin Peng, Qingyu Xue, Houning Lv, Hua Zhang, Yumei Qiu, Haichao Cheng, Yu Zhang, Zhiyong Yu, Weigan Shen

Pages: 2495-2503 Published online on: 16 March 2015

miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression

Ya-Sai Yao, Wen-Sheng Qiu, Ru-Yong Yao, Qian Zhang, Li‑Kun Zhuang, Fei Zhou, Li-Bin Sun, Lu Yue

Pages: 2504-2512 Published online on: 18 March 2015

Antiproliferative effects of β-blockers on human colorectal cancer cells

M. Coelho, M. Moz, G. Correia, A. Teixeira, R. Medeiros, L. Ribeiro

Pages: 2513-2520 Published online on: 23 March 2015

Mothers' acceptance of human papillomavirus (HPV) vaccination for daughters in a country with a high prevalence of HPV

Susanna Alder, Sofia Gustafsson, Claudia Perinetti, Miriam Mints, Karin Sundström, Sonia Andersson

Pages: 2521-2528 Published online on: 25 February 2015

Inhibition of microRNA-17/20a suppresses cell proliferation in gastric cancer by modulating UBE2C expression

Yingyi Zhang, Ting Han, Guo Wei, Yajie Wang

Pages: 2529-2536 Published online on: 05 March 2015

Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells

Qu Yang, Shanyong Zhang, Mingyang Kang, Rongpeng Dong, Jianwu Zhao

Pages: 2537-2544 Published online on: 04 March 2015

Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells

Takeshi Ishikawa, Satoko Adachi, Tetsuya Okayama, Satoshi Kokura, Katsura Mizushima, Toshifumi Doi, Tatsuzo Matsuyama, Naoyuki Sakamoto, Kazuhiro Katada, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa

Pages: 2545-2552 Published online on: 24 February 2015

Salidroside inhibits the growth of human breast cancer in vitro and in vivo

Gang Zhao, Aiping Shi, Zhimin Fan, Ye Du

Pages: 2553-2560 Published online on: 17 March 2015

Genome‑wide analysis of histone modifications by ChIP‑chip to identify silenced genes in gastric cancer

Xinjiang Zhu, Jian Liu, Xiaoyang Xu, Chundong Zhang, Dongqiu Dai

Pages: 2567-2574 Published online on: 27 February 2015

Effects of the knockdown of death-associated protein 3 expression on cell adhesion, growth and migration in breast cancer cells

Umar Wazir, Andrew J. Sanders, Ahmad M.A. Wazir, Lin Ye, Wen G. Jiang, Irina C. Ster, Anup K. Sharma, Kefah Mokbel

Pages: 2575-2582 Published online on: 02 March 2015

Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation by inhibiting angiotensin-(1-7)/Mas signaling

Bo Liu, Yu Liu, Yugang Jiang

Pages: 2583-2591 Published online on: 20 February 2015

miR-182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer

Yu Zhang, Xinying Wang, Zhongqiu Wang, Hui Tang, Hong Fan, Qiang Guo

Pages: 2592-2598 Published online on: 04 March 2015

MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas

Xu Zhang, Yang Teng, Fang Yang, Meng Wang, Xuan Hong, Lei-Guang Ye, Yi-Na Gao, Gong-Yan Chen

Pages: 2599-2605 Published online on: 27 February 2015

miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Quanxing Cao, Pingshuan Dong, Yanyu Wang, Junwei Zhang, Xinge Shi, Yongsheng Wang

Pages: 2606-2612 Published online on: 18 March 2015

BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR‑29b and enhancing MMP2 expression

Shutaro Habata, Masahiro Iwasaki, Asuka Sugio, Miwa Suzuki, Masato Tamate, Seiro Satohisa, Ryoichi Tanaka, Tsuyoshi Saito

Pages: 2613-2621 Published online on: 04 March 2015

OCT4B modulates OCT4A expression as ceRNA in tumor cells

Dong Li, Zheng-Kai Yang, Jing-Yi Bu, Chun-Yan Xu, Hui Sun, Jie-Bing Tang, Ping Lin, Wen Cheng, Ning Huang, Rong-Jun Cui, Xiao-Guang Yu, Xiu-Lan Zheng

Pages: 2622-2630 Published online on: 18 March 2015

Slug mediates nasopharyngeal carcinoma radioresistance via downregulation of PUMA in a p53-dependent and -independent manner

Ting Xu, Bin Fan, Chunjiang Lv, Dajiang Xiao

Pages: 2631-2638 Published online on: 23 March 2015

Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G2/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells

Jong-Yun Kim, Hye-Eun Choi, Hwi-Ho Lee, Ji-Sun Shin, Dong‑Hyun Shin, Jung-Hye Choi, Yong Sup Lee, Kyung-Tae Lee

Pages: 2639-2647 Published online on: 20 March 2015

Aberrant hypomethylation-mediated CD147 overexpression promotes aggressive tumor progression in human prostate cancer

Yu-Xiang Liang, Ru-Jun Mo, Hui-Chan He, Jia-Hong Chen, Jun Zou, Zhao-Dong Han, Jian-Ming Lu, Chao Cai, Yan-Ru Zeng, Wei-De Zhong, Chin-Lee Wu

Pages: 2648-2654 Published online on: 20 March 2015
Journal Cover

May 2015
Volume 33 Issue 5

Print ISSN: 1021-335X
Online ISSN: 1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.576 Ranked #33/202 Oncology
(total number of cites)

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