TREATMENT OF PATIENTS WITH METASTATIC GASTRIC-CANCER BY CONTINUOUS-INFUSION OF 5-FLUOROURACIL, CISPLATIN AND ETOPOSIDE

  • Authors: H IISHI, M TATSUTA, S TSUTSUI, S KITAMURA, Y NAGASAWA, S OKUDA
  • View Affiliations

  • Published online on: Saturday, January 1, 1994
  • Pages: 47-52
  • DOI: 10.3892/or.1.1.47

Abstract

The therapeutic effectiveness of continuous infusion of 5-fluorouracil and cisplatin, and etoposide (FEP) for treatment of metastatic gastric cancer was examined. Studies were made on 17 patients with gastric cancer with distant metastases. 5-fluorouracil (300 mg/m(2)/day) and cisplatin (80 mg/m(2)/day) were administered by continuous intravenous infusion for 120 and 24 hours, respectively; etoposide (60 mg/m(2)/day) was injected intravenously over a 2 hour period on days 2, 3 and 4. These chemotherapy treatments were repeated every 28 days. Partial, but not complete, remission was seen in four patients (24%). The treatment increased the survival times of patients with differentiated or Borrmann 2 or 3 type cancer, but not significantly. In many cases the treatment caused myelosuppression, but side effects were usually mild or moderate. It is concluded that infusion of 5-fluorouracil, etoposide and cisplatin is effective and well tolerated.
Journal Cover

January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
IISHI, H., TATSUTA, M., TSUTSUI, S., KITAMURA, S., NAGASAWA, Y., & OKUDA, S. (1994). TREATMENT OF PATIENTS WITH METASTATIC GASTRIC-CANCER BY CONTINUOUS-INFUSION OF 5-FLUOROURACIL, CISPLATIN AND ETOPOSIDE. Oncology Reports, 1(1), 47-52.
MLA
IISHI, TATSUTA, TSUTSUI, KITAMURA, NAGASAWA, and S OKUDA. "TREATMENT OF PATIENTS WITH METASTATIC GASTRIC-CANCER BY CONTINUOUS-INFUSION OF 5-FLUOROURACIL, CISPLATIN AND ETOPOSIDE." Oncology Reports Oncology Reports 1.1 (1994): 47-52.
Chicago
IISHI, TATSUTA, TSUTSUI, KITAMURA, NAGASAWA, and S OKUDA. "TREATMENT OF PATIENTS WITH METASTATIC GASTRIC-CANCER BY CONTINUOUS-INFUSION OF 5-FLUOROURACIL, CISPLATIN AND ETOPOSIDE." Oncology Reports Oncology Reports 1 no. 1 (1994): 47-52.