Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course

  • Authors: Kumiko Haruta, Shunji Matsunaga, Hiroshi Ito, Kyoji Hayashi, Masahiro Yokouchi, Toshiyuki Onishi, Setsuro Komiya
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  • Published online on: Tuesday, July 1, 2003
  • Pages: 1007-1010
  • DOI: 10.3892/or.10.4.1007

Abstract

Membranous lipodystrophy is known as Nasu-Hakola disease. The main symptoms of membranous lipodystrophy are those of a progressive presenile dementia due to sclerosing leukoencephalopathy with skeletal polycystic lesions. There is no report detailing long-term follow-up of patients with membranous lipodystrophy. We present a 56-year-old woman with this disease who has not manifested any typical neuropsychiatric symptoms during the 16-year follow-up, and thus has had an unusually benign clinical course. The patient underwent curettage and bone grafts. Periodic examinations have been continued for 16 years from discharge. No recurrence of lesions or occurrence of new cystic lesions has been noted. Computerized tomography and magnetic resonance imaging of the brain revealed none of the abnormal change which are reported in this disease. Our findings suggest that some patients with this disease may be fortunate enough to follow a relatively benign clinical course.
Journal Cover

July 2003
Volume 10 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Haruta, K., Matsunaga, S., Ito, H., Hayashi, K., Yokouchi, M., Onishi, T., & Komiya, S. (2003). Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course. Oncology Reports, 10(4), 1007-1010.
MLA
Haruta, Matsunaga, Ito, Hayashi, Yokouchi, Onishi, and Setsuro Komiya. "Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course." Oncology Reports Oncology Reports 10.4 (2003): 1007-1010.
Chicago
Haruta, Matsunaga, Ito, Hayashi, Yokouchi, Onishi, and Setsuro Komiya. "Membranous lipodystrophy (Nasu-Hakola disease) presenting an unusually benign clinical course." Oncology Reports Oncology Reports 10 no. 4 (2003): 1007-1010.