Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma

  • Authors: Maciej Lazarczyk, Tomasz Grzela, Justyna Niderla, Jakub Golab, Grazyna Korczak-Kowalska, Monika Oldak, Piotr Skopinski
  • View Affiliations

  • Published online on: Tuesday, July 1, 2003
  • Pages: 839-843
  • DOI: 10.3892/or.10.4.839

Abstract

Pentoxifylline (PTX), a methylxanthine derivative, is commonly used in patients suffering from peripheral vascular diseases. Besides its well-known hemorheological properties PTX has been found to decrease the secretion of some inflammatory cytokines such as TNF, IL-12 and IFN-γ. PTX also suppresses lymphocyte cytotoxicity, affecting mainly the perforin-dependent pathway. We investigated the influence of PTX on the splenocyte cytotoxicity and leukocyte infiltration in a murine colon adenocarcinoma model. We observed that PTX decreased the cytotoxic activity of isolated splenocytes against C-26 cells and reduced the inflammatory cell infiltration in the peritumoral tissue. Thus, our results strongly suggest the necessity of further studies concerning the safety of PTX use, especially in elderly patients or patients with already diagnosed cancer.
Journal Cover

July 2003
Volume 10 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lazarczyk, M., Grzela, T., Niderla, J., Golab, J., Korczak-Kowalska, G., Oldak, M., & Skopinski, P. (2003). Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma. Oncology Reports, 10(4), 839-843.
MLA
Lazarczyk, Grzela, Niderla, Golab, Korczak-Kowalska, Oldak, and Piotr Skopinski. "Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma." Oncology Reports Oncology Reports 10.4 (2003): 839-843.
Chicago
Lazarczyk, Grzela, Niderla, Golab, Korczak-Kowalska, Oldak, and Piotr Skopinski. "Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma." Oncology Reports Oncology Reports 10 no. 4 (2003): 839-843.