Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression

  • Authors: Nicoletta Ferrari, Laura Paleari, Giulio L. Palmisano, Paolo Tammaro, Giovanni Levi, Adriana Albini, Claudio Brigati
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  • Published online on: Tuesday, July 1, 2003
  • Pages: 973-977
  • DOI: 10.3892/or.10.4.973

Abstract

We investigated a possible relationship between apoptosis induction by fenretinide (4HPR) and the expression of a group of genes thought to be essential in morphogenesis and development, the DLX genes. We analyzed their expression under normal conditions or upon 4HPR stimulation in several tumor cell lines. We show that DLX2, DLX3 and DLX4 were expressed at higher levels in cell lines which where more sensitive to apoptotic induction, whereas DLX 5 and 6 appeared to segregate in a distinct functional compartment. Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients.
Journal Cover

July 2003
Volume 10 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Ferrari, N., Paleari, L., Palmisano, G., Tammaro, P., Levi, G., Albini, A., & Brigati, C. (2003). Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression. Oncology Reports, 10(4), 973-977.
MLA
Ferrari, Paleari, Palmisano, Tammaro, Levi, Albini, and Claudio Brigati. "Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression." Oncology Reports Oncology Reports 10.4 (2003): 973-977.
Chicago
Ferrari, Paleari, Palmisano, Tammaro, Levi, Albini, and Claudio Brigati. "Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression." Oncology Reports Oncology Reports 10 no. 4 (2003): 973-977.