Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

  • Authors:
    • Satoru Tokuyama
    • Seiichi Saito
    • Toshiko Takahashi
    • Chikara Ohyama
    • Akihiro Ito
    • Satoru Kanto
    • Makoto Satoh
    • Senji Hoshi
    • Mareyuki Endoh
    • Yoichi Arai
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/or.10.5.1097
  • Pages: 1097-1104
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Abstract

Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.

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September-October 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tokuyama S, Saito S, Takahashi T, Ohyama C, Ito A, Kanto S, Satoh M, Hoshi S, Endoh M, Arai Y, Arai Y, et al: Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncol Rep 10: 1097-1104, 2003.
APA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S. ... Arai, Y. (2003). Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. Oncology Reports, 10, 1097-1104. https://doi.org/10.3892/or.10.5.1097
MLA
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10.5 (2003): 1097-1104.
Chicago
Tokuyama, S., Saito, S., Takahashi, T., Ohyama, C., Ito, A., Kanto, S., Satoh, M., Hoshi, S., Endoh, M., Arai, Y."Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors". Oncology Reports 10, no. 5 (2003): 1097-1104. https://doi.org/10.3892/or.10.5.1097