High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival

  • Authors: Estrid V.S. Høgdall, Julia S. Johansen, Susanne K. Kjaer, Paul A. Price, Lise Christensen, Jan Blaakaer, Johannes E. Bock, Eva Glud, Claus K. Høgdall
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  • Published online on: Monday, September 1, 2003
  • Pages: 1535-1538
  • DOI: 10.3892/or.10.5.1535

Abstract

YKL-40 (human cartilage glycoprotein-39) is a member of family 18 glycosyl hydrolases. YKL-40 is a growth factor and is secreted by cancer cells. High serum levels of YKL-40 in patients with colorectal cancer and recurrent metastatic breast cancer have been associated with a poor prognosis. We evaluated the prognostic value of plasma YKL-40 in patients with primary ovarian cancer (OC). YKL-40 was determined by ELISA in plasma obtained preoperatively from 47 women with stage III OC and in plasma from 79 healthy females. The results showed that plasma YKL-40 was elevated compared to healthy females in 57% of the OC patients and was highest in the patients who died during the follow-up compared to the patients still alive (186 vs. 78 µg/l, p=0.002). Patients with high plasma YKL-40 (>130 µg/l) had significantly (p=0.0003) shorter survival than patients with normal plasma YKL-40. Multivariate Cox regression analysis showed that plasma YKL-40 (RH=3.95; 95% CI, 1.52-10.27; p=0.005) and radicality after primary surgery (RH=4.03; 95% CI, 1.81-8.97; p=0.001) were independent prognostic factors of survival, whereas age, histological type of tumour and serum CA125 had no independent prognostic value. In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients.
Journal Cover

September 2003
Volume 10 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
Høgdall, E., Johansen, J., Kjaer, S., Price, P., Christensen, L., Blaakaer, J., Bock, J., Glud, E., & Høgdall, C. (2003). High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncology Reports, 10(5), 1535-1538.
MLA
Høgdall, Johansen, Kjaer, Price, Christensen, Blaakaer, Bock, Glud, and Claus Høgdall. "High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival." Oncology Reports Oncology Reports 10.5 (2003): 1535-1538.
Chicago
Høgdall, Johansen, Kjaer, Price, Christensen, Blaakaer, Bock, Glud, and Claus Høgdall. "High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival." Oncology Reports Oncology Reports 10 no. 5 (2003): 1535-1538.