Nuclear β-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers

  • Authors:
    • Shin'ichi Miyamoto
    • Yasushi Endoh
    • Takahiro Hasebe
    • Genichiro Ishii
    • Keiji Kodama
    • Masato Goya
    • Masato Ono
    • Norio Saitoh
    • Tsutomu Chiba
    • Atsushi Ochiai
  • Corresponding author:
  • View Affiliations

  • Published online on: Sunday, August 1, 2004
  • Pages: 245-251 DOI: 10.3892/or.12.2.245

Abstract

β-catenin is well recognized to play a crucial role as a transcriptional factor during the early step of colorectal carcinogenesis. Some reports concerning the clinical implications of cytoplasmic and/or nuclear β-catenin accumulation are available, though their results vary. On the other hand, the clinical implication of nuclear accumulation of β-catenin in Dukes' D colorectal cancers (with distant metastasis) has not been investigated. To assess its value as a prognostic marker in this stage, we selected the cases with synchronous liver metastasis. Thirty-eight surgically resected primary and corresponding metastatic liver tumors were examined immunohistochemically and the relationships between nuclear β-catenin accumulation and clinicopathological variables were analyzed. Of the 38 primary colorectal cancers analyzed, 11 (29%) showed nuclear accumulation of β-catenin with cytoplasmic staining. Nuclear accumulation positivity was more frequently associated with lymph node metastasis than being negative [100% (11/11) vs. 67% (18/27), p=0.04]. There was a significant difference in median survival time between the nuclear β-catenin positive group (1130 days) and the negative group (2102 days: p=0.037). Interestingly, all of the patients (9/9) in the former group had died when the recurrence was in the liver, while 42% (8/19) in the latter group had survived even if the recurrence was in the liver (p=0.03). In conclusion, though these results were obtained in a small series of patients, nuclear accumulation of β-catenin may be a useful prognostic marker even in Dukes' D colorectal cancers.
Journal Cover

August 2004
Volume 12 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
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APA
Miyamoto, S., Endoh, Y., Hasebe, T., Ishii, G., Kodama, K., Goya, M. ... Ochiai, A. (2004). Nuclear β-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers. Oncology Reports, 12, 245-251. http://dx.doi.org/10.3892/or.12.2.245
MLA
Miyamoto, S., Endoh, Y., Hasebe, T., Ishii, G., Kodama, K., Goya, M., Ono, M., Saitoh, N., Chiba, T., Ochiai, A."Nuclear β-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers". Oncology Reports 12.2 (2004): 245-251.
Chicago
Miyamoto, S., Endoh, Y., Hasebe, T., Ishii, G., Kodama, K., Goya, M., Ono, M., Saitoh, N., Chiba, T., Ochiai, A."Nuclear β-catenin accumulation as a prognostic factor in Dukes' D human colorectal cancers". Oncology Reports 12, no. 2 (2004): 245-251. http://dx.doi.org/10.3892/or.12.2.245