search button

Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers

  • Authors:
    • Daisuke Yuki
    • Yu-Min Lin
    • Yoshitaka Fujii
    • Yusuke Nakamura
    • Yoichi Furukawa

  • View Affiliations

  • Published online on: August 1, 2004     https://doi.org/10.3892/or.12.2.275
  • Pages: 275-280
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Through analysis of genome-wide expression profiles on a cDNA microarray consisting of 23,040 human genes, we have been attempting to isolate novel molecular targets for diagnosis, treatment and prevention of colorectal carcinoma (CRC). Among the genes that were frequently transactivated in colorectal tumors, we identified a novel gene termed LEMD1 (LEM domain-containing 1) whose expression was elevated in 17 of 18 CRCs compared with their corresponding non-cancerous mucosae. Northern blotting revealed that LEMD1 was expressed only in testis among the 16 normal adult tissues examined. Subsequent analysis identified six alternatively spliced forms of the transcript in normal testis, but only one of them (656 nucleotides) was expressed in CRCs. Since the LEMD1 protein appears to fall in the category of cancer-testis antigens (CTAs), it may represent a promising target antigen for immunotherapy of CRCs.

Related Articles

Journal Cover

August 2004
Volume 12 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Yuki D, Lin Y, Fujii Y, Nakamura Y and Furukawa Y: Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. Oncol Rep 12: 275-280, 2004
APA
Yuki, D., Lin, Y., Fujii, Y., Nakamura, Y., & Furukawa, Y. (2004). Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers. Oncology Reports, 12, 275-280. https://doi.org/10.3892/or.12.2.275
MLA
Yuki, D., Lin, Y., Fujii, Y., Nakamura, Y., Furukawa, Y."Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers". Oncology Reports 12.2 (2004): 275-280.
Chicago
Yuki, D., Lin, Y., Fujii, Y., Nakamura, Y., Furukawa, Y."Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers". Oncology Reports 12, no. 2 (2004): 275-280. https://doi.org/10.3892/or.12.2.275