Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro

  • Authors:
    • Qing-Yi Lu
    • Maryam R. Sartippour
    • Mai N. Brooks
    • Qifeng Zhang
    • Mary Hardy
    • Vay Liang Go
    • Frederick P. Li
    • David Heber
  • Corresponding author:
  • View Affiliations

  • Published online on: Wednesday, September 1, 2004
  • Pages: 659-662 DOI: 10.3892/or.12.3.659

Abstract

This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 µg/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.
Journal Cover

September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
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APA
Lu, Q., Sartippour, M.R., Brooks, M.N., Zhang, Q., Hardy, M., Go, V.L. ... Heber, D. (2004). Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro. Oncology Reports, 12, 659-662. http://dx.doi.org/10.3892/or.12.3.659
MLA
Lu, Q., Sartippour, M. R., Brooks, M. N., Zhang, Q., Hardy, M., Go, V. L., Li, F. P., Heber, D."Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro". Oncology Reports 12.3 (2004): 659-662.
Chicago
Lu, Q., Sartippour, M. R., Brooks, M. N., Zhang, Q., Hardy, M., Go, V. L., Li, F. P., Heber, D."Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro". Oncology Reports 12, no. 3 (2004): 659-662. http://dx.doi.org/10.3892/or.12.3.659