Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro

  • Authors: Qing-Yi Lu, Maryam R. Sartippour, Mai N. Brooks, Qifeng Zhang, Mary Hardy, Vay Liang Go, Frederick P. Li, David Heber
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  • Published online on: Wednesday, September 1, 2004
  • Pages: 659-662
  • DOI: 10.3892/or.12.3.659

Abstract

This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 µg/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.
Journal Cover

September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Lu, Q., Sartippour, M., Brooks, M., Zhang, Q., Hardy, M., Go, V., Li, F., & Heber, D. (2004). Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro. Oncology Reports, 12(3), 659-662.
MLA
Lu, Sartippour, Brooks, Zhang, Hardy, Go, Li, and David Heber. "Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro." Oncology Reports Oncology Reports 12.3 (2004): 659-662.
Chicago
Lu, Sartippour, Brooks, Zhang, Hardy, Go, Li, and David Heber. "Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro." Oncology Reports Oncology Reports 12 no. 3 (2004): 659-662.