Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro
- Authors: Qing-Yi Lu, Maryam R. Sartippour, Mai N. Brooks, Qifeng Zhang, Mary Hardy, Vay Liang Go, Frederick P. Li, David Heber
Published online on: Wednesday, September 1, 2004
- Pages: 659-662
- DOI: 10.3892/or.12.3.659
This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 µg/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities.