The human myotubularin-related protein suppresses the growth of lung carcinoma cells

  • Authors:
    • Young Do Yoo
    • Sun Mi Cho
    • Jun Suk Kim
    • Yoon Soo Chang
    • Chul Min Ahn
    • Hyung Jung Kim
  • Corresponding author:
  • View Affiliations

  • Published online on: Wednesday, September 1, 2004
  • Pages: 667-671 DOI: 10.3892/or.12.3.667

Abstract

Herein, we report that the human myotubularin-related protein (KIAA0371) induced growth suppression of lung cancer cells. Colony formation assays demonstrated that the exogenous expression of the human myotubularin-related gene induced a significant growth inhibition of H1299 cells in which the expression of the human myotubularin-related gene was undetectable. Colony formation of these cells was reduced by 39% after transfection with this gene, as compared with the control vector. Cells stably transfected with this gene showed a reduction in growth of 48% compared with those cells transfected with the empty vector. We also showed that this negative regulation of the myotubularin-related protein is correlated with cell-cycle arrest at G1. In addition, we found that the cyclin-dependent kinase inhibitor, p27, is induced by increased expression of the human myotubularin-related gene. These results suggest that the human myotubularin-related protein can negatively regulate the growth of lung cancer cells.
Journal Cover

September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.527 Ranked #33/202 Oncology
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APA
Yoo, Y.D., Cho, S.M., Kim, J.S., Chang, Y.S., Ahn, C.M., & Kim, H.J. (2004). The human myotubularin-related protein suppresses the growth of lung carcinoma cells. Oncology Reports, 12, 667-671. http://dx.doi.org/10.3892/or.12.3.667
MLA
Yoo, Y. D., Cho, S. M., Kim, J. S., Chang, Y. S., Ahn, C. M., Kim, H. J."The human myotubularin-related protein suppresses the growth of lung carcinoma cells". Oncology Reports 12.3 (2004): 667-671.
Chicago
Yoo, Y. D., Cho, S. M., Kim, J. S., Chang, Y. S., Ahn, C. M., Kim, H. J."The human myotubularin-related protein suppresses the growth of lung carcinoma cells". Oncology Reports 12, no. 3 (2004): 667-671. http://dx.doi.org/10.3892/or.12.3.667