The human myotubularin-related protein suppresses the growth of lung carcinoma cells

  • Authors: Young Do Yoo, Sun Mi Cho, Jun Suk Kim, Yoon Soo Chang, Chul Min Ahn, Hyung Jung Kim
  • View Affiliations

  • Published online on: Wednesday, September 1, 2004
  • Pages: 667-671
  • DOI: 10.3892/or.12.3.667

Abstract

Herein, we report that the human myotubularin-related protein (KIAA0371) induced growth suppression of lung cancer cells. Colony formation assays demonstrated that the exogenous expression of the human myotubularin-related gene induced a significant growth inhibition of H1299 cells in which the expression of the human myotubularin-related gene was undetectable. Colony formation of these cells was reduced by 39% after transfection with this gene, as compared with the control vector. Cells stably transfected with this gene showed a reduction in growth of 48% compared with those cells transfected with the empty vector. We also showed that this negative regulation of the myotubularin-related protein is correlated with cell-cycle arrest at G1. In addition, we found that the cyclin-dependent kinase inhibitor, p27, is induced by increased expression of the human myotubularin-related gene. These results suggest that the human myotubularin-related protein can negatively regulate the growth of lung cancer cells.
Journal Cover

September 2004
Volume 12 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Yoo, Y., Cho, S., Kim, J., Chang, Y., Ahn, C., & Kim, H. (2004). The human myotubularin-related protein suppresses the growth of lung carcinoma cells. Oncology Reports, 12(3), 667-671.
MLA
Yoo, Cho, Kim, Chang, Ahn, and Hyung Kim. "The human myotubularin-related protein suppresses the growth of lung carcinoma cells." Oncology Reports Oncology Reports 12.3 (2004): 667-671.
Chicago
Yoo, Cho, Kim, Chang, Ahn, and Hyung Kim. "The human myotubularin-related protein suppresses the growth of lung carcinoma cells." Oncology Reports Oncology Reports 12 no. 3 (2004): 667-671.