CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule

  • Authors: D. H. Palmer, S. A. Hussain, R. Ganesan, P. W. Cooke, D. M.A. Wallace, L. S. Young, N. D. James
  • View Affiliations

  • Published online on: Friday, October 1, 2004
  • Pages: 679-682
  • DOI: 10.3892/or.12.4.679

Abstract

CD40, a member of the TNF receptor superfamily, is widely expressed on human immune cells. It is also frequently expressed on epithelial malignancies, suggesting that CD40 may contribute to the pathogenesis of some cancers. Activation of CD40 in cancer cells induces growth inhibition and sensitization to apoptotic stimuli. This study investigates CD40 expression in archival tissue from patients with prostate cancer. In all cases, normal prostatic acini expressed CD40, however, in 56 of 57 cases of prostate cancer no CD40 expression was detected. In the one other case, patchy CD40 expression was associated with prostatic in situ neoplasia. In conclusion, invasive prostate cancer is a CD40-negative tumour. These data may be relevant as a diagnostic tool; in providing insight into progression of cancer from normal epithelium; and in identifying novel therapeutic strategies for prostate cancer.
Journal Cover

October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Palmer, D., Hussain, S., Ganesan, R., Cooke, P., Wallace, D., Young, L., & James, N. (2004). CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule. Oncology Reports, 12(4), 679-682.
MLA
Palmer, Hussain, Ganesan, Cooke, Wallace, Young, and N. James. "CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule." Oncology Reports Oncology Reports 12.4 (2004): 679-682.
Chicago
Palmer, Hussain, Ganesan, Cooke, Wallace, Young, and N. James. "CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule." Oncology Reports Oncology Reports 12 no. 4 (2004): 679-682.