Prognostic value of Topoisomerase II in female breast cancer

  • Authors: Rumelia Koren, Lea Rath-Wolfson, Edward Ram, Ofer Ben Itzhac, Benny Schachter, Baruch Klein, Rivka Gal, Zeev Dreznik
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  • Published online on: Friday, October 1, 2004
  • Pages: 915-919
  • DOI: 10.3892/or.12.4.915

Abstract

Topoisomerase II-alpha (Topo II-alpha) is a nuclear enzyme. Its expression rises rapidly at the end of the S to G2/M phase and falls after the mitotic process ends. We have studied the immunohistochemical expression of Topo II-alpha in breast cancer and its correlation with the menopausal state, tumor type, size, lymph node metastases, stage, and estrogen and progesterone positivity. Histological sections from 50 breast cancers were immunohistochemically stained for Topo II-alpha. The percent of positive cells at the area of highest staining was recorded as Topo index. The correlation between the course of disease, survival and Topo II-alpha index was statistically significant, p<0.001. High-grade tumors showed higher Topo II-alpha levels, than those of intermediate and low-grade, p<0.01. A significant association was found between estrogen receptors positivity and Topo II-alpha, p<0.05. A higher Topo II-alpha index indicates higher probability for recurrence of the disease and overall survival. Therefore, Topo II-alpha expression has a prognostic value in breast carcinoma.
Journal Cover

October 2004
Volume 12 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Koren, R., Rath-Wolfson, L., Ram, E., Itzhac, O., Schachter, B., Klein, B., Gal, R., & Dreznik, Z. (2004). Prognostic value of Topoisomerase II in female breast cancer. Oncology Reports, 12(4), 915-919.
MLA
Koren, Rath-Wolfson, Ram, Itzhac, Schachter, Klein, Gal, and Zeev Dreznik. "Prognostic value of Topoisomerase II in female breast cancer." Oncology Reports Oncology Reports 12.4 (2004): 915-919.
Chicago
Koren, Rath-Wolfson, Ram, Itzhac, Schachter, Klein, Gal, and Zeev Dreznik. "Prognostic value of Topoisomerase II in female breast cancer." Oncology Reports Oncology Reports 12 no. 4 (2004): 915-919.