Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer

  • Authors:
    • A. Morán
    • P. Iniesta
    • C. García-Aranda
    • C. De Juan
    • A. Díaz-López
    • A. Sánchez-Pernaute
    • A. J. Torres
    • E. Díaz-Rubio
    • J. L. Balibrea
    • M. Benito
  • Corresponding author:
  • View Affiliations

  • Published online on: Saturday, January 1, 2005
  • Pages: 115-120 DOI: 10.3892/or.13.1.115

Abstract

The main aim of this study was to evaluate the clinical relevance of Gelatinases in colorectal cancer (CRC). Ninety-five CRCs and their paired normal tissues were investigated to detect total levels of MMP-9, MMP-2, and the tissue inhibitors TIMP-1 and TIMP-2. Also, pro-MMP and MMP activity, and potential associations with clinical parameters were estimated. MMP-9, MMP-2 and TIMP-1 levels were greater in CRCs than in normal tissues, differences being significant for MMP-9 and TIMP-1. However, TIMP-2 showed significantly lower levels in tumour samples. Moreover, significant differences in the state of activation between gelatinases were found. TIMP-1 low levels were significantly associated with poor clinical outcome of patients. According to these data, different roles have to be attributed to MMP-2 and MMP-9 in CRC progression. Moreover, TIMP-1 level evaluation emerges as the main prognostic factor in relation to Gelatinases A and B activity in CRC.
Journal Cover

January 2005
Volume 13 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A. ... Benito, M. (2005). Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncology Reports, 13, 115-120. http://dx.doi.org/10.3892/or.13.1.115
MLA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13.1 (2005): 115-120.
Chicago
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A. J., Díaz-Rubio, E., Balibrea, J. L., Benito, M."Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer". Oncology Reports 13, no. 1 (2005): 115-120. http://dx.doi.org/10.3892/or.13.1.115