Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer

  • Authors: A. Morán, P. Iniesta, C. García-Aranda, C. De Juan, A. Díaz-López, A. Sánchez-Pernaute, A. J. Torres, E. Díaz-Rubio, J. L. Balibrea, M. Benito
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  • Published online on: Saturday, January 1, 2005
  • Pages: 115-120
  • DOI: 10.3892/or.13.1.115

Abstract

The main aim of this study was to evaluate the clinical relevance of Gelatinases in colorectal cancer (CRC). Ninety-five CRCs and their paired normal tissues were investigated to detect total levels of MMP-9, MMP-2, and the tissue inhibitors TIMP-1 and TIMP-2. Also, pro-MMP and MMP activity, and potential associations with clinical parameters were estimated. MMP-9, MMP-2 and TIMP-1 levels were greater in CRCs than in normal tissues, differences being significant for MMP-9 and TIMP-1. However, TIMP-2 showed significantly lower levels in tumour samples. Moreover, significant differences in the state of activation between gelatinases were found. TIMP-1 low levels were significantly associated with poor clinical outcome of patients. According to these data, different roles have to be attributed to MMP-2 and MMP-9 in CRC progression. Moreover, TIMP-1 level evaluation emerges as the main prognostic factor in relation to Gelatinases A and B activity in CRC.
Journal Cover

January 2005
Volume 13 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Morán, A., Iniesta, P., García-Aranda, C., De Juan, C., Díaz-López, A., Sánchez-Pernaute, A., Torres, A., Díaz-Rubio, E., Balibrea, J., & Benito, M. (2005). Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer. Oncology Reports, 13(1), 115-120.
MLA
Morán, Iniesta, García-Aranda, De Juan, Díaz-López, Sánchez-Pernaute, Torres, Díaz-Rubio, Balibrea, and M. Benito. "Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer." Oncology Reports Oncology Reports 13.1 (2005): 115-120.
Chicago
Morán, Iniesta, García-Aranda, De Juan, Díaz-López, Sánchez-Pernaute, Torres, Díaz-Rubio, Balibrea, and M. Benito. "Clinical relevance of MMP-9, MMP-2, TIMP-1 and TIMP-2 in colorectal cancer." Oncology Reports Oncology Reports 13 no. 1 (2005): 115-120.