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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2005 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat

  • Authors:
    • Keiko Matono
    • Yutaka Ogata
    • Hideaki Tsuda
    • Yasumi Araki
    • Kazuo Shirouzu

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan
  • Pages: 389-395
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/or.13.3.389
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Abstract

We have investigated the efficacy and mechanisms of antineoplaston AS2-1 against post-operative lung metastasis following removal of implanted human colon cancer in nude rat. The influence of AS2-1 on in vitro KM12SM human colon carcinoma cell activities (growth, cell cycle, and apoptosis) was evaluated. AS2-1 was administered perorally after removal of the implanted KM12SM cecal cancer in nude rat. AS2-1 inhibited KM12SM cell proliferation through G1 cell arrest and, at a higher concentration, induction of apoptosis. AS2-1 showed significant reduction in lung metastasis at 5 weeks after cecal removal. The survival rate in the AS2-1 group was significantly higher than that in the control. TUNEL staining on the lung metastatic tumors revealed that the apoptosis index (AI) in the AS2-1 group was significantly higher. Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Matono K, Ogata Y, Tsuda H, Araki Y and Shirouzu K: Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncol Rep 13: 389-395, 2005.
APA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., & Shirouzu, K. (2005). Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncology Reports, 13, 389-395. https://doi.org/10.3892/or.13.3.389
MLA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13.3 (2005): 389-395.
Chicago
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13, no. 3 (2005): 389-395. https://doi.org/10.3892/or.13.3.389
Copy and paste a formatted citation
x
Spandidos Publications style
Matono K, Ogata Y, Tsuda H, Araki Y and Shirouzu K: Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncol Rep 13: 389-395, 2005.
APA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., & Shirouzu, K. (2005). Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat. Oncology Reports, 13, 389-395. https://doi.org/10.3892/or.13.3.389
MLA
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13.3 (2005): 389-395.
Chicago
Matono, K., Ogata, Y., Tsuda, H., Araki, Y., Shirouzu, K."Effects of antineoplaston AS2-1 against post-operative lung metastasis in orthotopically implanted colon cancer in nude rat". Oncology Reports 13, no. 3 (2005): 389-395. https://doi.org/10.3892/or.13.3.389
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