Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer

  • Authors: Anthony W.H. Chan, Michael W.Y. Chan, Tin-Lap Lee, Enders K.W. Ng, Wai-Keung Leung, James Y.W. Lau, Joanna H.M. Tong, Francis K.L. Chan, Ka-Fai To
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  • Published online on: Sunday, May 1, 2005
  • Pages: 937-941
  • DOI: 10.3892/or.13.5.937

Abstract

Death-associated protein kinase (DAP-kinase) is a serine/threonine kinase and a positive mediator of apoptosis. Down-regulation of DAP-kinase was associated with increased metastatic potential of tumors. Gene promoter hypermethylation could lead to down-regulation of DAP-kinase. We aimed to investigate the frequency of gene promoter methylation of DAP-kinase in gastric carcinoma (GCA) and assessed its association with clinicopathological features. One hundred and seven cases of gastric carcinoma were examined. The relevant clinical and pathological features, including survival data were reviewed. Methylation status was assessed by methylation-specific PCR (MSP). Seventy-four cases (69.2%) of GCA demonstrated promoter methylation of DAP-kinase. Methylation of DAP-kinase was observed in intestinal, diffuse and mixed type of GCA. It also occurred in similar frequency among antral, body and cardiac gastric cancer. No association between methylation status and age or gender was demonstrated. However, the methylated cases correlated with the presence of nodal metastasis (p=0.041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation.
Journal Cover

May 2005
Volume 13 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Chan, A., Chan, M., Lee, T., Ng, E., Leung, W., Lau, J., Tong, J., Chan, F., & To, K. (2005). Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer. Oncology Reports, 13(5), 937-941.
MLA
Chan, Chan, Lee, Ng, Leung, Lau, Tong, Chan, and Ka-Fai To. "Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer." Oncology Reports Oncology Reports 13.5 (2005): 937-941.
Chicago
Chan, Chan, Lee, Ng, Leung, Lau, Tong, Chan, and Ka-Fai To. "Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer." Oncology Reports Oncology Reports 13 no. 5 (2005): 937-941.