Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging

  • Authors:
    • N. Jassam
    • S.M. Bell
    • V. Speirs
    • P. Quirke
  • View Affiliations

  • Published online on: July 1, 2005     https://doi.org/10.3892/or.14.1.17
  • Pages: 17-21
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Abstract

Gender differences in the incidence and behaviour of colon cancer suggest a hormonal influence and epidemiological data suggest a protective effect for hormone replacement therapy. Recently, it has been shown that oestrogen receptor (ER) β is the predominant ER in colon tissue. The aim of this study was to examine the expression and distribution of ERβ in normal and colorectal cancer samples, using immunohistochemistry and (in a subset of patients) real-time quantitative reverse transcriptase polymerase chain reaction in a well-defined patient cohort and to correlate this with clinico-pathological outcome. Immunohistochemical analyses of normal colon revealed strong specific nuclear immuno-reactivity in all epithelial cells lining the colonic crypts. In colon cancer, ERβ expression was lost in 21% of samples irrespective of patient age or gender. Interestingly loss of ERβ expression was higher in left colon and rectal cancers (27%) compared to right colon cancers (8%). A correlation between loss of ERβ expression and advanced Dukes stage was observed. Loss of ERβ with increased Dukes' stage suggests that it may be affording a protective effect against colon carcinogenesis. Its presence may be a favourable prognostic marker in this disease and could explain the protective effect of oestrogens against colon cancer development.

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July 2005
Volume 14 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jassam N, Bell S, Speirs V and Quirke P: Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging. Oncol Rep 14: 17-21, 2005.
APA
Jassam, N., Bell, S., Speirs, V., & Quirke, P. (2005). Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging. Oncology Reports, 14, 17-21. https://doi.org/10.3892/or.14.1.17
MLA
Jassam, N., Bell, S., Speirs, V., Quirke, P."Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging". Oncology Reports 14.1 (2005): 17-21.
Chicago
Jassam, N., Bell, S., Speirs, V., Quirke, P."Loss of expression of oestrogen receptor β in colon cancer and its association with Dukes' staging". Oncology Reports 14, no. 1 (2005): 17-21. https://doi.org/10.3892/or.14.1.17