Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma

  • Authors: Makoto Furihata, Yuko Ono, Kazuhito Ichikawa, Shigeki Tomita, Takahiro Fujimori, Keiichi Kubota
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  • Published online on: Monday, August 1, 2005
  • Pages: 353-356
  • DOI: 10.3892/or.14.2.353

Abstract

Dendritic cells (DCs) are very potent antigen-presenting cells that play an essential role in the primary immune response to carcinoma. Tumor-infiltrating DCs have been found to be clinically significant in many human malignancies such as colon, stomach, lung, breast and hepatic carcinoma. However, clinical significance of activated and/or immature DCs in gallbladder carcinoma has not been reported yet. Thus, we immunohistochemically evaluated CD83+ DCs and CD1a+ DCs of cancerous and peritumoral area in 29 cases of resected gallbladder. In the results, CD83+ DCs were significantly fewer in cancerous area than that in peritumoral area (1.55/hpf vs. 4.26/hpf, p=0.0047), but the numbers of CD1a+ DCs did not differ (p=0.075). In addition, we defined a CD83 index as CD83+ DCs/(CD83+ DCs plus CD1a+ DCs), and analyzed the relationship between CD83 index and clinicopathological factors. The group with a higher CD83 index (index >0.316) showed significantly better prognosis than the group with a lower CD83 index (index ≤0.316) in cancerous and peritumoral areas. In conclusion, we suggest the importance of tumor-infiltrating CD83+ DCs as a useful prognostic factor for patients with gallbladder carcinoma.
Journal Cover

August 2005
Volume 14 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Furihata, M., Ono, Y., Ichikawa, K., Tomita, S., Fujimori, T., & Kubota, K. (2005). Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma. Oncology Reports, 14(2), 353-356.
MLA
Furihata, Ono, Ichikawa, Tomita, Fujimori, and Keiichi Kubota. "Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma." Oncology Reports Oncology Reports 14.2 (2005): 353-356.
Chicago
Furihata, Ono, Ichikawa, Tomita, Fujimori, and Keiichi Kubota. "Prognostic significance of CD83 positive, mature dendritic cells in the gallbladder carcinoma." Oncology Reports Oncology Reports 14 no. 2 (2005): 353-356.