Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer

  • Authors:
    • Hiroshi Inoue
    • Kenji Shibuta
    • Ayumi Matsuyama
    • Keishi Yoshinaga
    • Noriaki Sadanaga
    • Hiroaki Ueo
    • Graham F. Barnard
    • Masaki Mori
  • View Affiliations

  • Published online on: September 1, 2005     https://doi.org/10.3892/or.14.3.707
  • Pages: 707-712
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Abstract

Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. It has been reported that COMT polymorphism is a representative genetic trait related to the susceptibility of an individual to breast cancer. However, there is no consensus concerning the association between breast cancer in Japanese patients and COMT polymorphism. To analyze the polymorphism distribution in Japanese patients with breast cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used. Based on an analysis of 201 Japanese patients with breast cancer and 352 healthy control subjects, a significant difference was observed in either the distribution of genotypes (p=0.03) or allele frequencies between the two groups (p=0.01). The relative risk of breast cancer for genotypes (COMTMet/Met and COMTVal/Met) including the variant allele (COMTMet) was 1.47 compared to the wild allele (COMTVal) and homozygote (COMTVal/Val). Furthermore, the distribution of genotypes in post-menopausal patients with breast cancer showed a significant difference with that of healthy subjects of the same menopausal status (p=0.01). No significant difference was found between the distribution of genotypes and clinicopathological features of the cancer. These results suggest that COMT polymorphism may thus be implicated as a genetic trait affecting the susceptibility of an individual to breast cancer in a Japanese population and be an important genetic risk factor in the development of breast cancer in post-menopausal women.

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September 2005
Volume 14 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Inoue H, Shibuta K, Matsuyama A, Yoshinaga K, Sadanaga N, Ueo H, Barnard GF and Mori M: Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer. Oncol Rep 14: 707-712, 2005.
APA
Inoue, H., Shibuta, K., Matsuyama, A., Yoshinaga, K., Sadanaga, N., Ueo, H. ... Mori, M. (2005). Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer. Oncology Reports, 14, 707-712. https://doi.org/10.3892/or.14.3.707
MLA
Inoue, H., Shibuta, K., Matsuyama, A., Yoshinaga, K., Sadanaga, N., Ueo, H., Barnard, G. F., Mori, M."Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer". Oncology Reports 14.3 (2005): 707-712.
Chicago
Inoue, H., Shibuta, K., Matsuyama, A., Yoshinaga, K., Sadanaga, N., Ueo, H., Barnard, G. F., Mori, M."Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer". Oncology Reports 14, no. 3 (2005): 707-712. https://doi.org/10.3892/or.14.3.707