CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines

  • Authors: M. Stubbs, K. Khan, R. G. Wickremasinghe, K. Ganeshaguru, M. E. Caplin
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  • Published online on: Saturday, October 1, 2005
  • Pages: 1055-1058
  • DOI: 10.3892/or.14.4.1055

Abstract

The gastrin CCK2 pathway has been implicated in the development of various cancers including leukaemia. An autocrine or intracrine pathway may exist in the leukaemia cell that is involved in stimulating proliferation. We tested four leukaemia cell lines, KU812, ML-1, MOLT-4 and U937 for the existence of the CCK2 receptor and gastrin precursor protein using immunoblotting. We also assessed the effect of CCK2 antagonist PD 135 and both gastrin 17 and glycine-extended gastrin on the proliferation of the cell lines. We found immunoreactive CCK2 and gastrin precursors present in all 4 cell lines. We also observed a stimulatory effect on proliferation by gastrin and glycine-extended gastrin on 2 and 3 of the cell lines respectively and an inhibitory effect of PD 135 on all 4 cell lines. These results demonstrate that the gastrin-gastrin receptor axis is a potential target for new therapeutic strategies.
Journal Cover

October 2005
Volume 14 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Stubbs, M., Khan, K., Wickremasinghe, R., Ganeshaguru, K., & Caplin, M. (2005). CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines. Oncology Reports, 14(4), 1055-1058.
MLA
Stubbs, Khan, Wickremasinghe, Ganeshaguru, and M. Caplin. "CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines." Oncology Reports Oncology Reports 14.4 (2005): 1055-1058.
Chicago
Stubbs, Khan, Wickremasinghe, Ganeshaguru, and M. Caplin. "CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines." Oncology Reports Oncology Reports 14 no. 4 (2005): 1055-1058.