Clinical benefits of hepatocellular carcinoma surveillance: A single-center, hospital-based study

  • Authors: Naota Taura, Keisuke Hamasaki, Kazuhiko Nakao, Tatsuki Ichikawa, Daisuke Nishimura, Takashi Goto, Mariko Fukuta, Hiroshi Kawashimo, Yasuhide Motoyoshi, Hidetaka Shibata, Katsumi Eguchi
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  • Published online on: Saturday, October 1, 2005
  • Pages: 999-1003
  • DOI: 10.3892/or.14.4.999

Abstract

Although there is no definitive evidence that hepatocellular carcinoma (HCC) screening in high-risk groups improves survival, many physicians screen high-risk populations with various tools such as α-fetoprotein (AFP) and ultrasonography (USG). The aim of this study was to clarify clinical differences between HCC patients diagnosed by surveillance and those with incidentally detected HCC. Two hundred and seventy-one Japanese patients with HCC diagnosed between January 1991 and December 2001 were recruited. They were categorized into two groups: 178 patients (group 1) had subclinical HCC diagnosed by surveillance and 93 patients (group 2) presented with incidentally detected HCC. The tumor size was significantly smaller in group 1 compared to that of group 2 (2.8 vs. 5.6 cm; P<0.0001). A significantly higher proportion of patients in group 2 had multiple HCC and portal vein infiltration when compared to group 1. Eighty-six (48.3%) group 1 patients and 16 (17.2%) group 2 patients underwent local ablation treatment, which is a curative treatment available for small HCCs (P<0.0001). The cumulative actuarial survival rate was significantly higher in group 1 than in group 2 (P=0.0091). Early detection of HCC by surveillance may contribute to a greater chance of receiving effective treatment and prolonged survival, although a further prospective, randomized study is needed.
Journal Cover

October 2005
Volume 14 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Taura, N., Hamasaki, K., Nakao, K., Ichikawa, T., Nishimura, D., Goto, T., Fukuta, M., Kawashimo, H., Motoyoshi, Y., Shibata, H., & Eguchi, K. (2005). Clinical benefits of hepatocellular carcinoma surveillance: A single-center, hospital-based study. Oncology Reports, 14(4), 999-1003.
MLA
Taura, Hamasaki, Nakao, Ichikawa, Nishimura, Goto, Fukuta, Kawashimo, Motoyoshi, Shibata, and Katsumi Eguchi. "Clinical benefits of hepatocellular carcinoma surveillance: A single-center, hospital-based study." Oncology Reports Oncology Reports 14.4 (2005): 999-1003.
Chicago
Taura, Hamasaki, Nakao, Ichikawa, Nishimura, Goto, Fukuta, Kawashimo, Motoyoshi, Shibata, and Katsumi Eguchi. "Clinical benefits of hepatocellular carcinoma surveillance: A single-center, hospital-based study." Oncology Reports Oncology Reports 14 no. 4 (2005): 999-1003.