Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice

  • Authors: George Kossoy, Herzl Ben-Hur, Asher Elhayany, David F. Schneider, Nadja Kossoy, Itshak Zusman
  • View Affiliations

  • Published online on: Thursday, December 1, 2005
  • Pages: 1625-1629
  • DOI: 10.3892/or.14.6.1625

Abstract

In our previous studies, we showed that soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa have distinct tumor-preventive effects on chemically induced mammary cancer in rats and are able to repair the damage caused by tumorigenesis in its early stages. In the present study, we investigated whether these proteins can prevent the development of chemically induced tumors in mice. The study was performed on C3H/He mice which have the ability to develop many spontaneous tumors with age. Forty-four, 6-week-old mice were exposed twice at a 2-week interval to the carcinogen 9,10-dimethyl-1,2-benz(α)anthracene (DMBA), at a dose of 2 mg/mouse administered intragastrically. Two months later, the mice were divided into two groups. One group received sterile saline twice a week at a dose of 0.2 ml/mouse, intraperitoneally (i.p.). The other group received sTAA twice a week at a dose of about 10 µl in 0.2 ml of sterile saline/mouse, i.p. Periodically, all mice were checked for the presence of tumors. The experiment was terminated at week 35. Vaccination with sTAA increased the time of involvement of mice in the experiment, prevented the tumorigenic effect of DMBA, and inhibited further development of existing tumors.
Journal Cover

December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
Kossoy, G., Ben-Hur, H., Elhayany, A., Schneider, D., Kossoy, N., & Zusman, I. (2005). Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice. Oncology Reports, 14(6), 1625-1629.
MLA
Kossoy, Ben-Hur, Elhayany, Schneider, Kossoy, and Itshak Zusman. "Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice." Oncology Reports Oncology Reports 14.6 (2005): 1625-1629.
Chicago
Kossoy, Ben-Hur, Elhayany, Schneider, Kossoy, and Itshak Zusman. "Preventive effect of the soluble tumor-associated antigens on DMBA induced tumorigenesis in C3H/He mice." Oncology Reports Oncology Reports 14 no. 6 (2005): 1625-1629.