Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland

  • Authors: Ichiro Kurokawa, Keisuke Nishimura, Arata Hakamada, Ken-ichi Isoda, Kei-ichi Yamanaka, Hitoshi Mizutani, Airo Tsubura
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  • Published online on: Tuesday, August 1, 2006
  • Pages: 295-299
  • DOI: 10.3892/or.16.2.295

Abstract

We experienced two cases of cutaneous dermoid cysts (DC). To elucidate the histogenesis of DC, we have studied cytokeratin (CK) expression in DC using ten different anti-keratin antibodies against CK1, 7, 8, 10, 14, 15, 16, 17, 18 and 19, and anti-filaggrin (filament aggregating protein) antibody. In the cyst wall of DC, CK1 and 10 were expressed in suprabasal layer, and CK14 was limited to the basal layer. In sebaceous gland-like structures, CK14 was detected in sebaceous acinus, and CK17 was detected in sebaceous duct. The other CKs were not detected. Filaggrin was intensely detected in the granular layer in the cyst wall of DC. CK expression profile of DC was similar to follicular infundibulum and sebaceous gland. These results suggested that DC differentiates towards follicular infundibulum and mature sebaceous gland.
Journal Cover

August 2006
Volume 16 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Kurokawa, I., Nishimura, K., Hakamada, A., Isoda, K., Yamanaka, K., Mizutani, H., & Tsubura, A. (2006). Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland. Oncology Reports, 16(2), 295-299.
MLA
Kurokawa, Nishimura, Hakamada, Isoda, Yamanaka, Mizutani, and Airo Tsubura. "Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland." Oncology Reports Oncology Reports 16.2 (2006): 295-299.
Chicago
Kurokawa, Nishimura, Hakamada, Isoda, Yamanaka, Mizutani, and Airo Tsubura. "Cutaneous dermoid cyst: Cytokeratin and filaggrin expression suggesting differentiation towards follicular infundibulum and mature sebaceous gland." Oncology Reports Oncology Reports 16 no. 2 (2006): 295-299.