Prognostic significance of Cyclin A in epidermoid anal cancer

  • Authors: Per J. Nilsson, Claes Lenander, Carlos Rubio, Gert Auer, Olle Ljungqvist, Bengt Glimelius
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  • Published online on: Friday, September 1, 2006
  • Pages: 443-449
  • DOI: 10.3892/or.16.3.443

Abstract

Ultimately aiming at a more individualized therapeutic approach in epidermoid anal cancer, this study explored the prognostic and predictive impact of a set of tumour markers. From a population-based cohort of 276 patients with epidermoid anal cancer, treated according to prospective protocols, 215 pre-treatment biopsies were investigated using immunohistochemistry. The expression of p53, p21, Cyclin A and CD31 was measured semi-quantitatively. The expression rate was classified as high when immunostaining was seen in >5% of the tumour cells for p53 and p21, >20% in Cyclin A and, above median vessel count for CD31. Marker expression was correlated to survival and treatment response. A high Cyclin A expression correlated significantly with improved overall (77% vs 59%, p=0.005) and tumour-specific (81% vs 64%, p=0.009) survival at 5 years. Also, the locoregional failure rate was significantly lower in patients with a high Cyclin A expression (12% vs 24%, p<0.05). In a multivariate Cox analysis Cyclin A was an independent prognostic factor. A low p21 expression correlated with a reduced rate of locoregional failure (14% vs 27%, p<0.05) but no impact on survival was found. For p53 and CD31 no significant correlations were obtained. Cyclin A may be an indicator of radiosensitivity and a valuable prognostic marker in epidermoid anal cancer.
Journal Cover

September 2006
Volume 16 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Nilsson, P., Lenander, C., Rubio, C., Auer, G., Ljungqvist, O., & Glimelius, B. (2006). Prognostic significance of Cyclin A in epidermoid anal cancer. Oncology Reports, 16(3), 443-449.
MLA
Nilsson, Lenander, Rubio, Auer, Ljungqvist, and Bengt Glimelius. "Prognostic significance of Cyclin A in epidermoid anal cancer." Oncology Reports Oncology Reports 16.3 (2006): 443-449.
Chicago
Nilsson, Lenander, Rubio, Auer, Ljungqvist, and Bengt Glimelius. "Prognostic significance of Cyclin A in epidermoid anal cancer." Oncology Reports Oncology Reports 16 no. 3 (2006): 443-449.