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Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma

  • Authors:
    • Ichiro Kurokawa
    • Yoshiko Urakawa
    • Yuko Senba
    • Eriko Kawabata
    • Keisuke Nishimura
    • Youichi Omoto
    • Kazuya Tokime
    • Hitoshi Mizutani
    • Airo Tsubura

  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/or.16.3.473
  • Pages: 473-477
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Abstract

We report two cases of eccrine porocarcinoma (EPC), one of intrepidermal EPC (IEEPC) and one of intradermal invasive EPC (IDEPC) in an immunohistochemical study of cytokeratins (CK) using nine different anti-keratin antibodies against CK1, 7, 8, 10, 14, 16, 17, 18 and 19. IEEPC expressed terminal differentiated CK1 and CK10. In contrast, IDEPC expressed simple-epithelial keratins such as CK7, 8, 18 and 19. Keratin expression of IEEPC preserves the immunophenotypes of normal epidermis. IDEPC, however, expresses poorly differentiated keratin. These results suggest that the keratin profiles of EPC are correlated with the invasive degree and reflect the clinical prognosis of EPC.

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September 2006
Volume 16 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Kurokawa I, Urakawa Y, Senba Y, Kawabata E, Nishimura K, Omoto Y, Tokime K, Mizutani H and Tsubura A: Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma. Oncol Rep 16: 473-477, 2006
APA
Kurokawa, I., Urakawa, Y., Senba, Y., Kawabata, E., Nishimura, K., Omoto, Y. ... Tsubura, A. (2006). Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma. Oncology Reports, 16, 473-477. https://doi.org/10.3892/or.16.3.473
MLA
Kurokawa, I., Urakawa, Y., Senba, Y., Kawabata, E., Nishimura, K., Omoto, Y., Tokime, K., Mizutani, H., Tsubura, A."Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma". Oncology Reports 16.3 (2006): 473-477.
Chicago
Kurokawa, I., Urakawa, Y., Senba, Y., Kawabata, E., Nishimura, K., Omoto, Y., Tokime, K., Mizutani, H., Tsubura, A."Keratin profiles may differ between intraepidermal and intradermal invasive eccrine porocarcinoma". Oncology Reports 16, no. 3 (2006): 473-477. https://doi.org/10.3892/or.16.3.473