Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer

  • Authors: Hernán G. Farina, Monica Pomies, Daniel F. Alonso, Daniel E. Gomez
  • View Affiliations

  • Published online on: Sunday, October 1, 2006
  • Pages: 885-891
  • DOI: 10.3892/or.16.4.885

Abstract

Tumor invasion, angiogenesis and metastasis involve secretion of proteolytic enzymes and cell migration into blood vessels. Tumor cells are capable of degrading the extracellular matrix via a proteolytic cascade that includes urokinase-type plasminogen activator (uPA) and matrix metalloproteases (MMPs). We have investigated the antitumor and antiangiogenic properties of soy isoflavone genistein in B16 melanoma and F3II mammary carcinoma mouse models. At non-cytotoxic concentrations (0.1-50 µM) genistein induced dose-dependent spindle-cell morphology and significantly reduced motility in both cell lines. Genistein inhibited uPA secreted by F3II cell monolayers, while inducing an increase in the proteolytic activity of B16 cells. On the contrary, the compound did not modify the MMP-9 and -2 produced by tumor cells. In vivo, i.p. administration of genistein at a dose of 10 mg/kg/day reduced tumor-induced angiogenesis in syngeneic mice implanted with B16 or F3II cells. Similar antiangiogenic effects were obtained with a soybean-based diet. This data suggest that tumor cell migration and proteolysis may be associated with the antitumor and antiangiogenic activity of soy isoflavone genistein.
Journal Cover

October 2006
Volume 16 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Farina, H., Pomies, M., Alonso, D., & Gomez, D. (2006). Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncology Reports, 16(4), 885-891.
MLA
Farina, Pomies, Alonso, and Daniel Gomez. "Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer." Oncology Reports Oncology Reports 16.4 (2006): 885-891.
Chicago
Farina, Pomies, Alonso, and Daniel Gomez. "Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer." Oncology Reports Oncology Reports 16 no. 4 (2006): 885-891.