CAN THE LOSS OF NEGATIVE REGULATION THEORY BE COMPATIBLE WITH THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES - (REVIEW)

  • Authors: G CALIN, D STEFANESCU
  • View Affiliations

  • Published online on: Friday, September 1, 1995
  • Pages: 875-878
  • DOI: 10.3892/or.2.5.875

Abstract

The hematological malignancies evolution exhibits significant differences with the solid tissue tumor development, especially in the initiation step. The loss of negative regulation theory of carcinogenesis was unambiguously demonstrated in the field of colorectal neoplasia, but up to date, several lines of inquiry failed to imply the dysregulation of suppressor genes as an etiologic event in the pathogenesis of leukemias and lymphomas. Considering the peculiarities of self-renewing hemopoietic cells, we propose in this communication a reconciliation of the loss of negative regulation theory with the blood malignancies development.
Journal Cover

September 1995
Volume 2 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
CALIN, G., & STEFANESCU, D. (1995). CAN THE LOSS OF NEGATIVE REGULATION THEORY BE COMPATIBLE WITH THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES - (REVIEW). Oncology Reports, 2(5), 875-878.
MLA
CALIN, and D STEFANESCU. "CAN THE LOSS OF NEGATIVE REGULATION THEORY BE COMPATIBLE WITH THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES - (REVIEW)." Oncology Reports Oncology Reports 2.5 (1995): 875-878.
Chicago
CALIN, and D STEFANESCU. "CAN THE LOSS OF NEGATIVE REGULATION THEORY BE COMPATIBLE WITH THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES - (REVIEW)." Oncology Reports Oncology Reports 2 no. 5 (1995): 875-878.