VASCULAR ENDOTHELIAL GROWTH-FACTOR PRODUCTION IS STIMULATED IN RESPONSE TO GROWTH-FACTORS IN HUMAN GLIOMA-CELLS

  • Authors: S KOOCHEKPOUR, A MERZAK, GJ PILKINGTON
  • View Affiliations

  • Published online on: Wednesday, November 1, 1995
  • Pages: 1059-1061
  • DOI: 10.3892/or.2.6.1059

Abstract

Neovascularization is essential for tumour growth and is mediated by physiological substances produced by tumours. Vascular endothelial growth factor (VEGF) is one such potent angiogenic factor. Human gliomas, the most important class of intrinsic brain tumours, express VEGF both in vivo and in vitro. Factors involved in the control of VEGF production by glioma cells are not well known. In this study, we investigated the role of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and platelet derived growth factors (PDGF) on VEGF production by four different glioma cell lines in vitro. With the exception of PDGF A/A and B/B in one cell line, all growth factors differentially stimulated VEGF production in all cell lines investigated. These data suggest that VEGF production in human glioma may be regulated by other growth factors which are also known to be expressed in such tumours.
Journal Cover

November 1995
Volume 2 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
KOOCHEKPOUR, S., MERZAK, A., & PILKINGTON, G. (1995). VASCULAR ENDOTHELIAL GROWTH-FACTOR PRODUCTION IS STIMULATED IN RESPONSE TO GROWTH-FACTORS IN HUMAN GLIOMA-CELLS. Oncology Reports, 2(6), 1059-1061.
MLA
KOOCHEKPOUR, MERZAK, and GJ PILKINGTON. "VASCULAR ENDOTHELIAL GROWTH-FACTOR PRODUCTION IS STIMULATED IN RESPONSE TO GROWTH-FACTORS IN HUMAN GLIOMA-CELLS." Oncology Reports Oncology Reports 2.6 (1995): 1059-1061.
Chicago
KOOCHEKPOUR, MERZAK, and GJ PILKINGTON. "VASCULAR ENDOTHELIAL GROWTH-FACTOR PRODUCTION IS STIMULATED IN RESPONSE TO GROWTH-FACTORS IN HUMAN GLIOMA-CELLS." Oncology Reports Oncology Reports 2 no. 6 (1995): 1059-1061.