Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells

  • Authors: David B. Shennan, Jean Thomson
  • View Affiliations

  • Published online on: Wednesday, October 1, 2008
  • Pages: 885-889
  • DOI: 10.3892/or_00000087

Abstract

It has been suggested that system L (LAT1/CD98hc) is up-regulated in cancer cells, including breast tumour cells, and is therefore a promising molecular target to inhibit or limit tumour cell growth. In view of this, we have examined the effect of BCH and other inhibitors of system L on the growth of MCF-7, ZR-75-1 and MDA-MB-231 cells. Treating cells with BCH markedly inhibited the metabolism of WST-1 in a dose-dependent fashion. Similarly, melphalan and D-leucine inhibited the growth of cultured breast cancer cells whereas MeAIB, an inhibitor of system A, was without effect. The effects of BCH and melphalan on cell growth were non-additive suggesting that both compounds were acting at a single locus. The results indicate that system L is required to maintain MCF-7, ZR-75-1 and MDA-MB-231 cell growth and support the notion that LAT1/CD98hc may be a suitable target to inhibit breast cancer progression.
Journal Cover

October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Shennan, D., & Thomson, J. (2008). Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. Oncology Reports, 20(4), 885-889.
MLA
Shennan, and Jean Thomson. "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells." Oncology Reports Oncology Reports 20.4 (2008): 885-889.
Chicago
Shennan, and Jean Thomson. "Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells." Oncology Reports Oncology Reports 20 no. 4 (2008): 885-889.