Positive KL-6 mucin expression combined with decreased membranous β-catenin expression indicates worse prognosis in colorectal carcinoma

  • Authors: Wei Zhang, Wei Tang, Yoshinori Inagaki, Ming Qiu, Huan-Li Xu, Xun Li, Yasuhiko Sugawara, Hirokazu Nagawa, Munehiro Nakata, Norihiro Kokudo
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  • Published online on: Saturday, November 1, 2008
  • Pages: 1013-1019
  • DOI: 10.3892/or_00000103

Abstract

Interaction of MUC1 with β-catenin plays a significant role in tumor progression and invasion. However, the clinical significance of coexpression of MUC1 and subcellular β-catenin expression in colorectal carcinoma remains unclear. The present study evaluated the clinicopathological significance of their combined expression for predicting prognosis. Seventy-seven colorectal carcinomas were subjected to immunohistochemical staining with anti-MUC1 KL-6 mucin and anti-β-catenin monoclonal antibody. Positive KL-6 mucin expression was correlated with decreased membranous β-catenin expression (P=0.022), while no correlation was found between positive KL-6 expression and nuclear β-catenin expression (P=0.142). Preservation of membranous β-catenin expression was detected in 35 cases (45.5%) and decreased membranous β-catenin expression was found in 42 cases (54.5%). Negative KL-6 expression was detected in 31 cases (41.3%) and positive expression was seen in 46 cases (59.7%). Combined positive KL-6 expression and decreased membranous β-catenin expression was found in 30 patients (39.0%), whose survival was significantly worse than that of patients with other expression patterns for these two molecules (53.3 vs. 84.4%, P=0.005). Multivariate analysis showed that this combination was as an independent predictor of survival. We concluded that the combined pattern of positive KL-6 expression and decreased membranous β-catenin expression by colorectal carcinoma is a useful biomarker for distinguishing a subgroup of patients with a worse prognosis.
Journal Cover

November 2008
Volume 20 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Zhang, W., Tang, W., Inagaki, Y., Qiu, M., Xu, H., Li, X., Sugawara, Y., Nagawa, H., Nakata, M., & Kokudo, N. (2008). Positive KL-6 mucin expression combined with decreased membranous β-catenin expression indicates worse prognosis in colorectal carcinoma. Oncology Reports, 20(5), 1013-1019.
MLA
Zhang, Tang, Inagaki, Qiu, Xu, Li, Sugawara, Nagawa, Nakata, and Norihiro Kokudo. "Positive KL-6 mucin expression combined with decreased membranous β-catenin expression indicates worse prognosis in colorectal carcinoma." Oncology Reports Oncology Reports 20.5 (2008): 1013-1019.
Chicago
Zhang, Tang, Inagaki, Qiu, Xu, Li, Sugawara, Nagawa, Nakata, and Norihiro Kokudo. "Positive KL-6 mucin expression combined with decreased membranous β-catenin expression indicates worse prognosis in colorectal carcinoma." Oncology Reports Oncology Reports 20 no. 5 (2008): 1013-1019.