AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells

  • Authors: Wei Pan, Hui Yang, Cong Cao, Xiuzu Song, Brittany Wallin, Rebecca Kivlin, Shan Lu, Gang Hu, Wen Di, Yinsheng Wan
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  • Published online on: Monday, December 1, 2008
  • Pages: 1553-1559
  • DOI: 10.3892/or_00000179

Abstract

AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase, serves as an energy sensor in all eukaryotic cells. Recent findings suggest that AMPK activation strongly suppresses cell proliferation and induces cell apoptosis in a variety of cancer cells. Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells. Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death. We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation. Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.
Journal Cover

December 2008
Volume 20 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., & Wan, Y. (2008). AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncology Reports, 20(6), 1553-1559.
MLA
Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, and Yinsheng Wan. "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." Oncology Reports Oncology Reports 20.6 (2008): 1553-1559.
Chicago
Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, and Yinsheng Wan. "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." Oncology Reports Oncology Reports 20 no. 6 (2008): 1553-1559.