Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma

  • Authors:
    • Hanna Ronkainen
    • Markku H. Vaarala
    • Saila Kauppila
    • Ylermi Soini
    • Timo K. Paavonen
    • Jenni Rask
    • Pasi Hirvikoski
  • View Affiliations

  • Published online on: June 1, 2009     https://doi.org/10.3892/or_00000383
  • Pages: 1519-1523
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Abstract

Renal cell carcinoma (RCC) is a malignancy with increasing incidence. Despite the well-known prognostic factors - the stage, grade and histological subtype - the clinical course of RCC can seem quite random. The aim of this study was to evaluate markers of the oxidative system as candidate prognostic factors for RCC. Our study population consisted of 152 patients who underwent operation for RCC between 1990 and 1999. The tumours were examined with three immunohistochemical markers of the oxidative system, thioredoxin (Trx), NF-E2-related factor (Nfr2) and BTB-Kelch type substrate adaptor protein (Keap1). Cytoplasmic Keap1 staining was related to poorer prognosis in renal cancer-specific survival. The difference was statistically significant (P=0.02). Keap1 staining was associated with a more advanced stage and a higher nuclear grade. Cytoplasmic Trx staining was associated with a trend of better prognosis in renal cancer-specific survival. Nfr2 staining was not a prognostic factor in renal cancer-specific survival. In RCC, Keap1 is associated with a more advanced disease, a higher grade and a poorer prognosis.

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June 2009
Volume 21 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ronkainen H, Vaarala MH, Kauppila S, Soini Y, Paavonen TK, Rask J and Hirvikoski P: Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncol Rep 21: 1519-1523, 2009.
APA
Ronkainen, H., Vaarala, M.H., Kauppila, S., Soini, Y., Paavonen, T.K., Rask, J., & Hirvikoski, P. (2009). Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncology Reports, 21, 1519-1523. https://doi.org/10.3892/or_00000383
MLA
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21.6 (2009): 1519-1523.
Chicago
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21, no. 6 (2009): 1519-1523. https://doi.org/10.3892/or_00000383