Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke

  • Authors: Alberto Izzotti, Francesco D'Agostini, Patrizia Larghero, Cristina Cartiglia, Giorgia Travaini, Roumen Balansky, Vernon E. Steele, Silvio De Flora
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  • Published online on: Tuesday, September 1, 2009
  • Pages: 469-474
  • DOI: 10.3892/or_00000458

Abstract

Mice are particularly susceptible to carcinogens when exposure starts early in life. We evaluated the expression of stem cell antigen-1 (Sca-1) gene in the lung of variously aged CD-1 mice, either untreated or exposed to environmental cigarette smoke (ECS) and/or to a light source. Sca-1 expression progressively decreased with age. The expression of Sca-1 gene and the amount of Sca-1 protein, which was exclusively localized in endothelial cells of the pulmonary vasculature, were significantly upregulated in mice exposed either to ECS or ECS plus light throughout the weaning period, starting at birth. These findings may contribute to explain the high vulnerability of mouse lung early in life.
Journal Cover

September 2009
Volume 22 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
Izzotti, A., D'Agostini, F., Larghero, P., Cartiglia, C., Travaini, G., Balansky, R., Steele, V., & De Flora, S. (2009). Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke. Oncology Reports, 22(3), 469-474.
MLA
Izzotti, D'Agostini, Larghero, Cartiglia, Travaini, Balansky, Steele, and Silvio De Flora. "Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke." Oncology Reports Oncology Reports 22.3 (2009): 469-474.
Chicago
Izzotti, D'Agostini, Larghero, Cartiglia, Travaini, Balansky, Steele, and Silvio De Flora. "Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke." Oncology Reports Oncology Reports 22 no. 3 (2009): 469-474.