Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience

  • Authors:
    • Koichiro Yamakado
    • Yasuhiro Inoue
    • Motoshi Takao
    • Haruyuki Takaki
    • Atsuhiro Nakatsuka
    • Junji Uraki
    • Masataka Kashima
    • Masato Kusunoki
    • Hideto Shimpo
    • Kan Takeda
  • View Affiliations

  • Published online on: Thursday, October 1, 2009
  • Pages: 885-891
  • DOI: 10.3892/or_00000513

Abstract

This study was undertaken to evaluate long-term results of radiofrequency (RF) ablation in patients with colorectal lung metastases and to stratify patients benefitting from lung RF ablation. Lung RF ablation was performed in 78 patients with 198 colorectal lung metastases. Safety, local tumor progression, and survival were evaluated retrospectively. The mean follow-up period after the 140 lung RF ablation sessions was 24.6±7.6 months. Pneumothorax and pleural effusion requiring chest tube placement occurred respectively in 18 (12.9%, 18/140) and 2 (1.4%, 2/140) sessions. The respective 1-, 3- and 5-year local tumor progression rates were 10.1% (95% CI, 2.9-17.3%), 20.6% (95% CI, 8.9-22.2%) and 20.6% (95% CI, 8.9-22.2%). The 1-, 3- and 5-year survival rates were 83.9% (95% CI, 75.2-92.7%), 56.1% (95% CI, 41.7-70.5%) and 34.9% (95% CI, 18.0-51.9%), with median survival time of 38.0 months. Univariate analysis revealed maximum tumor diameter of 3 cm or less, single-lung metastasis, lack of extrapulmonary metastasis and normal carcinoembryonic antigen (CEA) level as better prognostic factors. The latter two were significant independent prognostic factors. The 1-, 3- and 5-year survival rates were 97.7% (95% CI, 93.3-100%), 82.5% (95% CI, 68.2-96.8%) and 57.0% (95% CI, 34.7-79.2%) in 54 patients with no extrapulmonary metastases and 96.9% (95% CI, 90.8-100%), 86.1% (95% CI, 71.1-100%) and 62.5% (95% CI, 36.3-88.6%) in 33 patients with negative CEA levels. Lung RF ablation is a safe and useful therapeutic option. These identified prognostic factors will help to stratify patients who benefit from lung RF ablation.
Journal Cover

October 2009
Volume 22 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Yamakado, K., Inoue, Y., Takao, M., Takaki, H., Nakatsuka, A., Uraki, J., Kashima, M., Kusunoki, M., Shimpo, H., & Takeda, K. (2009). Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience. Oncology Reports, 22(4), 885-891.
MLA
Yamakado, Inoue, Takao, Takaki, Nakatsuka, Uraki, Kashima, Kusunoki, Shimpo, and Kan Takeda. "Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience." Oncology Reports Oncology Reports 22.4 (2009): 885-891.
Chicago
Yamakado, Inoue, Takao, Takaki, Nakatsuka, Uraki, Kashima, Kusunoki, Shimpo, and Kan Takeda. "Long-term results of radiofrequency ablation in colorectal lung metastases: Single center experience." Oncology Reports Oncology Reports 22 no. 4 (2009): 885-891.