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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2010 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2010 Volume 23 Issue 1

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Article

Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin

  • Authors:
    • Patrizia Gazzerro
    • Anna M. Malfitano
    • Maria Chiara Proto
    • Antonietta Santoro
    • Simona Pisanti
    • Maria Gabriella Caruso
    • Maria Notarnicola
    • Caterina Messa
    • Chiara Laezza
    • Gabriella Misso
    • Michele Caraglia
    • Maurizio Bifulco
  • View Affiliations / Copyright

    Affiliations: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (Salerno), Italy
  • Pages: 171-175
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/or_00000619
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Abstract

Rimonabant (SR141716), a highly selective cannabinoid receptor antagonist, exerts along with its anti-obesity action, pleiotropic functions affecting a broad range of diseases, from obesity-related co-morbidities to drug dependence and cancer. Several studies suggested an anti-tumour activity of rimonabant in several in vitro and in vivo models. In this study, we compared the anti-proliferative effect of SR141716 in the human colon cancer cell line DLD-1 with oxaliplatin, one of the cytotoxic drugs currently used in the treatment of colorectal cancer. We show that SR141716 inhibits DLD-1 cell proliferation similarly to oxaliplatin and if administered in combination SR141716 potentiated the inhibitory effect caused by oxaliplatin. Assessment of drug interaction was performed calculating combination index that showed a strong synergistic effect between the two drugs added to cells in combination. Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings.

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Copy and paste a formatted citation
Spandidos Publications style
Gazzerro P, Malfitano AM, Proto MC, Santoro A, Pisanti S, Caruso MG, Notarnicola M, Messa C, Laezza C, Misso G, Misso G, et al: Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncol Rep 23: 171-175, 2010.
APA
Gazzerro, P., Malfitano, A.M., Proto, M.C., Santoro, A., Pisanti, S., Caruso, M.G. ... Bifulco, M. (2010). Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncology Reports, 23, 171-175. https://doi.org/10.3892/or_00000619
MLA
Gazzerro, P., Malfitano, A. M., Proto, M. C., Santoro, A., Pisanti, S., Caruso, M. G., Notarnicola, M., Messa, C., Laezza, C., Misso, G., Caraglia, M., Bifulco, M."Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin". Oncology Reports 23.1 (2010): 171-175.
Chicago
Gazzerro, P., Malfitano, A. M., Proto, M. C., Santoro, A., Pisanti, S., Caruso, M. G., Notarnicola, M., Messa, C., Laezza, C., Misso, G., Caraglia, M., Bifulco, M."Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin". Oncology Reports 23, no. 1 (2010): 171-175. https://doi.org/10.3892/or_00000619
Copy and paste a formatted citation
x
Spandidos Publications style
Gazzerro P, Malfitano AM, Proto MC, Santoro A, Pisanti S, Caruso MG, Notarnicola M, Messa C, Laezza C, Misso G, Misso G, et al: Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncol Rep 23: 171-175, 2010.
APA
Gazzerro, P., Malfitano, A.M., Proto, M.C., Santoro, A., Pisanti, S., Caruso, M.G. ... Bifulco, M. (2010). Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin. Oncology Reports, 23, 171-175. https://doi.org/10.3892/or_00000619
MLA
Gazzerro, P., Malfitano, A. M., Proto, M. C., Santoro, A., Pisanti, S., Caruso, M. G., Notarnicola, M., Messa, C., Laezza, C., Misso, G., Caraglia, M., Bifulco, M."Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin". Oncology Reports 23.1 (2010): 171-175.
Chicago
Gazzerro, P., Malfitano, A. M., Proto, M. C., Santoro, A., Pisanti, S., Caruso, M. G., Notarnicola, M., Messa, C., Laezza, C., Misso, G., Caraglia, M., Bifulco, M."Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin". Oncology Reports 23, no. 1 (2010): 171-175. https://doi.org/10.3892/or_00000619
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