| 4-Chlorobenzoyl berbamine induces apoptosis and G2/M cell cycle arrest through the PI3K/Akt and NF-κB signal pathway in lymphoma cells |
Authors: Hua-Ping Du, Jia-Kun Shen, Min Yang, Yun-Qui Wang, Xiang-Qui Yuan, Qiu-Ling Ma, Jie Jin |
Affiliations:
Institute of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang 310003, P.R. China
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Doi: 10.3892/or_00000688 |
Pages: 709-716 |
Abstract:
Berbamine is an herbal compound derived from Berberis amurensis, which is used in Chinese traditional medicine. However, few studies have investigated this anti-tumor effect or the underlying mechanisms of berbamine on lymphoma cells. We investigate the effect, as well as the mechanism of action, of 4-chlorobenzoyl berbamine (BBD9) on Raji, L428, Namalwa and Jurkat lymphoma cells lines. Our findings show that BBD9 inhibits cell proliferation and induces cell apoptosis in lymphoma cell lines as well as G2/M cell cycle arrest through PI3K/Akt and NF-κB signaling pathways in a caspase-dependent manner. These results may provide new insights into the treatment of lymphoma.
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