HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis

  • Authors:
    • Nobuyuki Bandoh
    • Takeshi Ogino
    • Akihiro Katayama
    • Miki Takahara
    • Akihiro Katada
    • Tatsuya Hayashi
    • Yasuaki Harabuchi
  • View Affiliations

  • Published online on: Thursday, April 1, 2010
  • Pages: 933-939
  • DOI: 10.3892/or_00000717

Abstract

HLA class I antigen processing machinery plays a crucial role in the generation of peptides from endogeneously synthesized proteins and in their presentation to cytotoxic T lymphocytes. The purpose of this study was to analyze the downregulation of HLA class I antigen, transporter associated with antigen processing (TAP) and tapasin in primary and metastatic lesions of head and neck squamous cell carcinoma (HNSCC) and to compare TAP, tapasin and HLA class I antigen downregulation in metastatic lesions with that of primary lesions. We analyzed expression levels of TAP1, TAP2, tapasin and HLA class I antigen in 25 primary and autologous metastatic lesions by staining formalin-fixed, paraffin-embedded tissue sections in the immunoperoxidase reaction. We identified the expression levels of TAP1, TAP2, tapasin and HLA class I antigen were coordinately downregulated in both primary and metastatic lesions and were significantly lower in metastatic lesions than in autologous primary lesions tested. HLA class I antigen downregulation in metastatic lesion was significantly associated with reduced disease-free survival of patients (P<0.05). Multivariate Cox proportional hazards model analysis identified negativity of HLA class I antigen as an independent prognostic marker. HLA class I antigen and TAP are likely to be downregulated in metastatic lesions compared with primary lesions in HNSCC. The higher frequency of HLA class I antigen and TAP down-regulation in metastases play a role in the clinical course of the disease.
Journal Cover

April 2010
Volume 23 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Bandoh, N., Ogino, T., Katayama, A., Takahara, M., Katada, A., Hayashi, T., & Harabuchi, Y. (2010). HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis . Oncology Reports, 23(4), 933-939.
MLA
Bandoh, Ogino, Katayama, Takahara, Katada, Hayashi, and Yasuaki Harabuchi. "HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis ." Oncology Reports Oncology Reports 23.4 (2010): 933-939.
Chicago
Bandoh, Ogino, Katayama, Takahara, Katada, Hayashi, and Yasuaki Harabuchi. "HLA class I antigen and transporter associated with antigen processing downregulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis ." Oncology Reports Oncology Reports 23 no. 4 (2010): 933-939.