Role of CDK8 and β-catenin in colorectal adenocarcinoma

  • Authors:
    • Jong-Og Seo
    • Song Iy Han
    • Sung-Chul Lim
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/or_00000858
  • Pages: 285-291
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Colorectal adenocarcinoma is a major cause of morbidity and mortality. The Wnt/β-catenin pathway plays an important role in colon cancers. However, relatively little is known about the regulatory mechanism of β-catenin in colon cancers. CDK8 is a cyclin-dependent kinase (CDK) member of the mediator complex that couples transcriptional regulators to the basal transcriptional machinery, and is implicated in the transcriptional regulation of key pathways involved in colon cancers. To determine the relationship between CDK8 and β-catenin expressions, a population-based study was conducted for immunohistochemical staining analysis of tumor tissues, and Western blot analysis and CDK8 interference studies of colon cancer cell lines. The hypothesis that colorectal cancers with CDK8 expression have distinct clinical, prognostic and molecular attributes was tested. Among 127 colorectal cancers, CDK8 expression was detected in 96 (76%) tumors by immunohistochemistry. CDK8 and β-catenin expression had significant positive correlation with carcinogenesis, tumor progression and patient survival. Immunohistochemically, CDK8 expression in colorectal cancer was independently associated with β-catenin activation (P=0.0002). However, β-catenin expression was not completely suppressed by CDK8 interference in the colon cancer cell lines HCT-116, HT-29 and SNU-C5. These data support a potential link between CDK8 and β-catenin, and suggest that CDK8 may identify a subset of colon cancer patients with a poor prognosis. However, control of CDK8 is not an effective therapeutic strategy through β-catenin regulation of general colon cancer.

Related Articles

Journal Cover

July 2010
Volume 24 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Seo J, Han SI and Lim S: Role of CDK8 and β-catenin in colorectal adenocarcinoma . Oncol Rep 24: 285-291, 2010.
APA
Seo, J., Han, S.I., & Lim, S. (2010). Role of CDK8 and β-catenin in colorectal adenocarcinoma . Oncology Reports, 24, 285-291. https://doi.org/10.3892/or_00000858
MLA
Seo, J., Han, S. I., Lim, S."Role of CDK8 and β-catenin in colorectal adenocarcinoma ". Oncology Reports 24.1 (2010): 285-291.
Chicago
Seo, J., Han, S. I., Lim, S."Role of CDK8 and β-catenin in colorectal adenocarcinoma ". Oncology Reports 24, no. 1 (2010): 285-291. https://doi.org/10.3892/or_00000858